Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness
about
Respiratory epithelial cells require Toll-like receptor 4 for induction of human beta-defensin 2 by lipopolysaccharidePostulates for validating TLR4 agonistsCrystal structures of human MD-2 and its complex with antiendotoxic lipid IVaThe inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge.N-linked glycosylation at Asn3 and the positively charged residues within the amino-terminal domain of the c1 inhibitor are required for interaction of the C1 Inhibitor with Salmonella enterica serovar typhimurium lipopolysaccharide and lipid A.Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses.Effects of polyclonal IgG derived from patients with different clinical types of the antiphospholipid syndrome on monocyte signaling pathways.Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory ResponseIdentification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signalingInsights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection.Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation.FLICE-like inhibitory protein (FLIP) protects against apoptosis and suppresses NF-kappaB activation induced by bacterial lipopolysaccharideModulating LPS signal transduction at the LPS receptor complex with synthetic Lipid A analoguesStudies of the TLR4-associated protein MD-2 using yeast-display and mutational analysesActivation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepaciaExpression of toll-like receptor 4 and MD-2 gene and protein in Kupffer cells after ischemia-reperfusion in rat liver graft.TLR2 and TLR4 stimulation differentially induce cytokine secretion in human neonatal, adult, and murine mononuclear cells.Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2.Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2.The role of TLR activation in inflammation.N-linked glycosylation is required for c1 inhibitor-mediated protection from endotoxin shock in mice.Role of Toll-like receptors in activation of porcine alveolar macrophages by porcine reproductive and respiratory syndrome virusRadioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high-affinity ligand for TLR4.Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxinIsolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations.Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer.Alcoholic liver disease and the gut-liver axis.Innate affairs of allergens.Recognition of lipid A variants by the TLR4-MD-2 receptor complex.Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin.Transcriptional regulation of beta-defensin-2 by lipopolysaccharide in cultured human cervical carcinoma (HeLa) cells.Exogenous MD-2 confers lipopolysaccharide responsiveness to human corneal epithelial cells with intracellular expression of TLR4 and CD14.Paclitaxel binding to human and murine MD-2.Transfer of monomeric endotoxin from MD-2 to CD14: characterization and functional consequences.Mechanism regulating cell surface expression and activation of Toll-like receptor 4.Dual receptors and distinct pathways mediate interleukin-1 receptor-associated kinase degradation in response to lipopolysaccharide. Involvement of CD14/TLR4, CR3, and phosphatidylinositol 3-kinase.Altered immune function of monocytes in different stages of patients with acute on chronic liver failure.Mutational analysis of membrane and soluble forms of human MD-2.
P2860
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P2860
Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Separate functional domains of ...... opolysaccharide responsiveness
@ast
Separate functional domains of ...... opolysaccharide responsiveness
@en
Separate functional domains of ...... opolysaccharide responsiveness
@nl
type
label
Separate functional domains of ...... opolysaccharide responsiveness
@ast
Separate functional domains of ...... opolysaccharide responsiveness
@en
Separate functional domains of ...... opolysaccharide responsiveness
@nl
prefLabel
Separate functional domains of ...... opolysaccharide responsiveness
@ast
Separate functional domains of ...... opolysaccharide responsiveness
@en
Separate functional domains of ...... opolysaccharide responsiveness
@nl
P1476
Separate functional domains of ...... opolysaccharide responsiveness
@en
P2093
Jack L Strominger
P304
P356
10.4049/JIMMUNOL.171.10.5272
P407
P577
2003-11-15T00:00:00Z