A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
about
Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumorsBiochemical analysis of the EJC reveals two new factors and a stable tetrameric protein coreeIF4A3 is a novel component of the exon junction complexIsolation and characterization of post-splicing lariat-intron complexesIdentification of a novel component C2ORF3 in the lariat-intron complex: lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover pathwaySplicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex componentsThe DEAD-box RNA helicase-like Utp25 is an SSU processome component.U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylationMethyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA.The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay.Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.Assays for the identification and prioritization of drug candidates for spinal muscular atrophyCyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.Functional association of the Microprocessor complex with the spliceosome.Chemical treatment enhances skipping of a mutated exon in the dystrophin gene.Identification of the specific interactors of the human lariat RNA debranching enzyme 1 proteinA quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis.Preparation of splicing competent nuclear extracts.Introns play an essential role in splicing-dependent formation of the exon junction complex.Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export.Splicing-independent recruitment of spliceosomal small nuclear RNPs to nascent RNA polymerase II transcripts.Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication.Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complexCharacterization of Rous sarcoma virus polyadenylation site use in vitroPrimary microRNA transcript retention at sites of transcription leads to enhanced microRNA production.hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity.Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing.In vivo BiFC analysis of Y14 and NXF1 mRNA export complexes: preferential localization within and around SC35 domains.Assembly and mobility of exon-exon junction complexes in living cells.p300/CBP-associated factor drives DEK into interchromatin granule clusters.Tip110 binding to U6 small nuclear RNA and its participation in pre-mRNA splicing.Flexibility in the site of exon junction complex deposition revealed by functional group and RNA secondary structure alterations in the splicing substrate.Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitmentTranscriptome-Wide Identification of RNA Targets of Arabidopsis SERINE/ARGININE-RICH45 Uncovers the Unexpected Roles of This RNA Binding Protein in RNA Processing.The mitotic phosphorylation of p54(nrb) modulates its RNA binding activity.Lariat Formation and 5'-Splice Site CleavageFormation of Exon Junction ComplexCBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.
P2860
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P2860
A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex
description
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2004
@ast
im Februar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 20 February 2004)
@en
vedecký článok (publikovaný 2004/02/20)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/02/20)
@nl
наукова стаття, опублікована в лютому 2004
@uk
name
A simple whole cell lysate sys ...... the exon-exon junction complex
@ast
A simple whole cell lysate sys ...... the exon-exon junction complex
@en
A simple whole cell lysate sys ...... the exon-exon junction complex
@nl
type
label
A simple whole cell lysate sys ...... the exon-exon junction complex
@ast
A simple whole cell lysate sys ...... the exon-exon junction complex
@en
A simple whole cell lysate sys ...... the exon-exon junction complex
@nl
prefLabel
A simple whole cell lysate sys ...... the exon-exon junction complex
@ast
A simple whole cell lysate sys ...... the exon-exon junction complex
@en
A simple whole cell lysate sys ...... the exon-exon junction complex
@nl
P2860
P356
P1476
A simple whole cell lysate sys ...... the exon-exon junction complex
@en
P2093
Gideon Dreyfuss
Naoyuki Kataoka
P2860
P304
P356
10.1074/JBC.M307692200
P407
P577
2004-02-20T00:00:00Z