Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation
about
Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotypeProtein O-fucosyltransferase 1 is an essential component of Notch signaling pathwaysFringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligandsNotch ligands are substrates for protein O-fucosyltransferase-1 and FringeNotch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse developmentFringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant miceO-fucosylation of DLL3 is required for its function during somitogenesisFringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1Role of glycans and glycosyltransferases in the regulation of Notch signalingFringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region.Fucose: biosynthesis and biological function in mammals.Glycosylation regulates Notch signalling.Fringe controls naïve CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models.Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factorsT-cell differentiation of multipotent hematopoietic cell line EML in the OP9-DL1 coculture system.A deficiency of lunatic fringe is associated with cystic dilation of the rete testis.Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype.N-glycoproteome analysis of the secretome of human metastatic hepatocellular carcinoma cell lines combining hydrazide chemistry, HILIC enrichment and mass spectrometryNotch signaling in the immune system.Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling.Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision.Regulation of Notch signaling by glycosylation.Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions.Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptorThe many facets of Notch ligands.Role of unusual O-glycans in intercellular signalingNOTCH signaling in Sertoli cells regulates gonocyte fateManic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.Patterning and cell fate in the inner ear: a case for Notch in the chicken embryo.Significance of glycosylation in Notch signaling.Roles of Pofut1 and O-fucose in mammalian Notch signaling.Non-small-cell lung carcinoma: role of the Notch signaling pathway.Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway.Dynamical states, possibilities and propagation of stress signal.Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe.Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats.In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe.
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P2860
Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation
description
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im Juli 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 13 July 2001)
@en
vedecký článok (publikovaný 2001/07/13)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/07/13)
@nl
наукова стаття, опублікована в липні 2001
@uk
name
Manic fringe and lunatic fring ...... different signaling modulation
@ast
Manic fringe and lunatic fring ...... different signaling modulation
@en
Manic fringe and lunatic fring ...... different signaling modulation
@nl
type
label
Manic fringe and lunatic fring ...... different signaling modulation
@ast
Manic fringe and lunatic fring ...... different signaling modulation
@en
Manic fringe and lunatic fring ...... different signaling modulation
@nl
prefLabel
Manic fringe and lunatic fring ...... different signaling modulation
@ast
Manic fringe and lunatic fring ...... different signaling modulation
@en
Manic fringe and lunatic fring ...... different signaling modulation
@nl
P2093
P2860
P356
P1476
Manic fringe and lunatic fring ...... different signaling modulation
@en
P2093
P2860
P304
P356
10.1074/JBC.M103473200
P407
P577
2001-07-13T00:00:00Z