Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4
about
Role of the UPS in Liddle syndromeCOMMD1 downregulates the epithelial sodium channel through Nedd4-2Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and functionWW domains provide a platform for the assembly of multiprotein networksPhosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expressionCalcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibitionUbiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channelInteraction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulationHrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathwaysAlternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.The WNKs: atypical protein kinases with pleiotropic actions.Abnormal regulation of ENaC: syndromes of salt retention and salt wasting by the collecting duct.Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport.Regulation of the epithelial sodium channel by accessory proteinsThe Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture.Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool.Ion channels in renal disease.Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel.Efficient and specific rescue of human immunodeficiency virus type 1 budding defects by a Nedd4-like ubiquitin ligase.Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligasesTGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of β-ENaC in a Human Alveolar Epithelial Cell Line.NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor.Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference.Phosphatase inhibitors increase the open probability of ENaC in A6 cells.The role of Nedd4-1 WW domains in binding and regulating human organic anion transporter 1.A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes.A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel.Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel.Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle.
P2860
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P2860
Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4
description
2001 nî lūn-bûn
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2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
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name
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@ast
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@en
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@nl
type
label
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@ast
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@en
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@nl
prefLabel
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@ast
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@en
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@nl
P2093
P2860
P356
P1476
Multiple WW domains, but not t ...... ial Na+ channel by human Nedd4
@en
P2093
D B Bucher
F J McDonald
P M Snyder
P2860
P304
P356
10.1074/JBC.M011487200
P407
P577
2001-07-27T00:00:00Z