Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501
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Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in ratsSyntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptorsCharacterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptorsPositive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEPPSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in ratsTrans-activation between 7TM domains: implication in heterodimeric GABAB receptor activationPositive allosteric modulation of GABAB receptors ameliorates sensorimotor gating in rodent models.Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors.Ligand-induced rearrangements of the GABA(B) receptor revealed by fluorescence resonance energy transfer.Structure and ligand recognition of class C GPCRsDiscovery of a Negative Allosteric Modulator of GABAB ReceptorsType B GABA receptors contribute to the restoration of balance during vestibular compensation in mice.Bitopic ligands: all-in-one orthosteric and allosteric.GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo.The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptorAdministration of GABA(B) receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference.Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats.Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in ratsEvaluation of peripheral versus central effects of GABA(B) receptor activation using a novel, positive allosteric modulator of the GABA(B) receptor ADX71943, a pharmacological tool compound with a fully peripheral activity profile.Interferometric methods for label-free molecular interaction studiesA Gut Feeling about GABA: Focus on GABA(B) Receptors.GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitizationGABAB receptor-positive modulators: brain region-dependent effects.GABAB receptor upregulates fragile X mental retardation protein expression in neuronsEffects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons.Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discoveryComputational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled ReceptorsIdentification of acidic residues in the extracellular loops of the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ and a positive allosteric modulator.Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor.Opposite effects of KCTD subunit domains on GABA(B) receptor-mediated desensitizationDiscriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12)Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate ReceptorsAllosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective.Complex GABAB receptor complexes: how to generate multiple functionally distinct units from a single receptor.Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA.Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives.GABAB receptor allosteric modulators exhibit pathway-dependent and species-selective activity.Label-free quantification of membrane-ligand interactions using backscattering interferometry.GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area.
P2860
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P2860
Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
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2001年论文
@wuu
name
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@ast
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@en
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@nl
type
label
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@ast
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@en
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@nl
prefLabel
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@ast
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@en
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@nl
P2093
P1476
Positive allosteric modulation ...... d its aldehyde analog CGP13501
@en
P2093
J Mosbacher
K Hofstetter
K Kaupmann
K Lingenhoehl
P304
P407
P577
2001-11-01T00:00:00Z