Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)
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The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injuryThe Role of Stefin B in Neuro-inflammationCathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateCell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progressionCathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pHCystatin B deficiency sensitizes neurons to oxidative stress in progressive myoclonus epilepsy, EPM1Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficitsProteomic profiling of the epileptic dentate gyrus.Cystatin C rescues degenerating neurons in a cystatin B-knockout mouse model of progressive myoclonus epilepsy.Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficitsA role for stefin B (cystatin B) in inflammation and endotoxemia.Protective mechanisms by cystatin C in neurodegenerative diseases.Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.Progressive volume loss and white matter degeneration in cstb-deficient mice: a diffusion tensor and longitudinal volumetry MRI study.Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer ProgressionSensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay.Characterization of a rare Unverricht-Lundborg disease mutation.The role of cystatins in cells of the immune system.Molecular background of EPM1-Unverricht-Lundborg disease.Cysteine cathepsins in neurological disorders.Transcriptomic analysis in the leech Theromyzon tessulatum: involvement of cystatin B in innate immunity.HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat NeurotoxicityCystatin C in aging and in Alzheimer's disease.Insights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor.Intracellular aggregation of human stefin B: confocal and electron microscopy study.Human stefin B normal and patho-physiological role: molecular and cellular aspects of amyloid-type aggregation of certain EPM1 mutants.Role of cystatin C in neuroprotection and its therapeutic implications.Picrotoxin-induced convulsions and lysosomal function in the rat brainIn vitro study of stability and amyloid-fibril formation of two mutants of human stefin B (cystatin B) occurring in patients with EPM1.Loss of lysosomal association of cystatin B proteins representing progressive myoclonus epilepsy, EPM1, mutations.iTRAQ-Based Identification of Proteins Related to Muscle Growth in the Pacific Abalone, Haliotis discus hannai.Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins.Cleavage of the myristoylated alanine-rich C kinase substrate (MARCKS) by cysteine cathepsins in cells and tissues of stefin B-deficient mice.Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1).Altered tryptophan metabolism in the brain of cystatin B-deficient mice: a model system for progressive myoclonus epilepsy.Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice.Long-term effects of recurrent neonatal seizures on neurobehavioral function and related gene expression and its intervention by inhibitor of cathepsin B.Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice
P2860
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P2860
Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@ast
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@en
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@nl
type
label
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@ast
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@en
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@nl
prefLabel
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@ast
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@en
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@nl
P2093
P356
P1476
Cathepsin B but not cathepsins ...... sive myoclonus epilepsy (EPM1)
@en
P2093
Alex Vilaythong
Christoph Peters
Jeffrey L Noebels
Len A Pennacchio
Megan K Houseweart
P304
P356
10.1002/NEU.10253
P407
P577
2003-09-15T00:00:00Z