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Charting a Path to Success in Virtual ScreeningImplications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical functionIn silico prediction of mutant HIV-1 proteases cleaving a target sequenceCaught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate †Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallographyCatalytic Water Co-Existing with a Product Peptide in the Active Site of HIV-1 Protease Revealed by X-Ray Structure AnalysisHow Much Binding Affinity Can be Gained by Filling a Cavity?The L76V Drug Resistance Mutation Decreases the Dimer Stability and Rate of Autoprocessing of HIV-1 Protease by Reducing Internal Hydrophobic ContactsCapturing the Reaction Pathway in Near-Atomic-Resolution Crystal Structures of HIV-1 ProteaseSynthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease InhibitorsStructural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycinStrong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a ProteinTeaching foundational topics and scientific skills in biochemistry within the conceptual framework of HIV protease.Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors.Model system for high-throughput screening of novel human immunodeficiency virus protease inhibitors in Escherichia coliMolecular docking screens using comparative models of proteinsComprehensive bioinformatic analysis of the specificity of human immunodeficiency virus type 1 protease.Transition states of native and drug-resistant HIV-1 protease are the same.Effects of HIV-1 protease on cellular functions and their potential applications in antiretroviral therapy.Computational mutation scanning and drug resistance mechanisms of HIV-1 protease inhibitorsStrategies for assessing proton linkage to bimolecular interactions by global analysis of isothermal titration calorimetry dataInhibitor design by wrapping packing defects in HIV-1 proteins.Protease Inhibitors for Patients With HIV-1 Infection: A Comparative Overview.Virtual Screening of Indonesian Herbal Database as HIV-1 Protease Inhibitor.Pentacycloundecane lactam vs lactone norstatine type protease HIV inhibitors: binding energy calculations and DFT study.Marketed nonsteroidal anti-inflammatory agents, antihypertensives, and human immunodeficiency virus protease inhibitors: as-yet-unused weapons of the oncologists' arsenal.Function-based mutation-resistant synthetic signaling device activated by HIV-1 proteolysisSynthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function.Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity.Intramolecular regulation of the sequence-specific mRNA interferase activity of MazF fused to a MazE fragment with a linker cleavable by specific proteasesSmall molecules targeting severe acute respiratory syndrome human coronavirusSpecific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules.Discovery of HIV Type 1 Aspartic Protease Hit Compounds through Combined Computational Approaches.Prediction of HIV-1 protease cleavage site using a combination of sequence, structural, and physicochemical features.How similar are enzyme active site geometries derived from quantum mechanical theozymes to crystal structures of enzyme-inhibitor complexes? Implications for enzyme design.Bioinformatic approaches for modeling the substrate specificity of HIV-1 protease: an overview.Elucidating the druggable interface of protein-protein interactions using fragment docking and coevolutionary analysis.Human immunodeficiency virus-1 gp120 V3 loop for anti-acquired immune deficiency syndrome drug discovery: computer-aided approaches to the problem solving.Heme and HO-1 Inhibition of HCV, HBV, and HIV.Proteomics in the investigation of HIV-1 interactions with host proteins.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
HIV-1 protease: mechanism and drug discovery
@ast
HIV-1 protease: mechanism and drug discovery
@en
HIV-1 protease: mechanism and drug discovery
@nl
type
label
HIV-1 protease: mechanism and drug discovery
@ast
HIV-1 protease: mechanism and drug discovery
@en
HIV-1 protease: mechanism and drug discovery
@nl
prefLabel
HIV-1 protease: mechanism and drug discovery
@ast
HIV-1 protease: mechanism and drug discovery
@en
HIV-1 protease: mechanism and drug discovery
@nl
P3181
P356
P1476
HIV-1 protease: mechanism and drug discovery
@en
P2093
Ashraf Brik
Chi-Huey Wong
P3181
P356
10.1039/B208248A
P407
P577
2003-01-07T00:00:00Z