The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse
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The WASP and WAVE family proteinsDOCK8 deficiency impairs CD8 T cell survival and function in humans and miceProline-serine-threonine phosphatase interacting protein 1 inhibition of T-cell receptor signaling depends on its SH3 domainCooperative interactions at the SLP-76 complex are critical for actin polymerizationPyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathwayInteraction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cellsAction and Traction: Cytoskeletal Control of Receptor Triggering at the Immunological SynapseActin cytoskeletal defects in immunodeficiencyAbelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activationLinking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector functionF-BAR family proteins, emerging regulators for cell membrane dynamic changes-from structure to human diseases.Regulation of the formation and trafficking of vesicles from Golgi by PCH family proteins during chemotaxisPACSIN2 regulates cell adhesion during gastrulation in Xenopus laevis.The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation.Early endosomes associated with dynamic F-actin structures are required for late trafficking of H. pylori VacA toxin.The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration.Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutantsSingle-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.Wiskott-Aldrich syndrome: a comprehensive review.Wiskott-Aldrich syndrome/X-linked thrombocytopenia in China: Clinical characteristic and genotype-phenotype correlation.WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.The mature activating natural killer cell immunologic synapse is formed in distinct stages.Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function.Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome proteinNuclear role of WASp in gene transcription is uncoupled from its ARP2/3-dependent cytoplasmic role in actin polymerization.Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1β levelsPathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes.T-cell receptor signaling to integrins.Structural characterization of a capping protein interaction motif defines a family of actin filament regulators.The Wiskott-Aldrich syndrome protein permits assembly of a focused immunological synapse enabling sustained T-cell receptor signaling.Regulation of cytoskeletal dynamics at the immune synapse: new stars join the actin troupeSynergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretionImpaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome.Synapses: sites of cell recognition, adhesion, and functional specification.Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.BAR proteins in cancer and blood disorders
P2860
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P2860
The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@ast
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@en
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@nl
type
label
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@ast
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@en
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@nl
prefLabel
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@ast
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@en
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@nl
P2093
P1433
P1476
The Wiskott-Aldrich syndrome p ...... n of the immunological synapse
@en
P2093
Deborah Field
Jinyi Zhang
Karen Badour
Katherine A Siminovitch
Lynne A Hardy
Mary K H McGavin
Vik Rampersad
P304
P356
10.1016/S1074-7613(02)00516-2
P407
P577
2003-01-01T00:00:00Z