The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth
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Critical role for Kalirin in nerve growth factor signaling through TrkA.An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domSGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration.The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activationSUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1Neurotrophin-regulated signalling pathwaysFunction and regulation of the Rho guanine nucleotide exchange factor TrioA signaling network for patterning of neuronal connectivity in the Drosophila brainThe C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipidsEchovirus 30 induced neuronal cell death through TRIO-RhoA signaling activationPlekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPasesLocal phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowthDifferential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extensionTransient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neuronsTrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesisControl of dendritic morphogenesis by Trio in Drosophila melanogasterRegulation of Kalirin by Cdk5The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion.Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions.Signaling between focal adhesion kinase and trio.The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells.Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory networkTrio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum.Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation.Intermolecular steric inhibition of Ephexin4 is relieved by Elmo1.Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activationADP-ribosylation factor 6 regulates mammalian myoblast fusion through phospholipase D1 and phosphatidylinositol 4,5-bisphosphate signaling pathways.Identification of novel neuronal isoforms of the Rho-GEF Trio.Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon.Identification of a mitotic Rac-GEF, Trio, that counteracts MgcRacGAP function during cytokinesisA loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation.Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signalingSolo/Trio8, a membrane-associated short isoform of Trio, modulates endosome dynamics and neurite elongation.Control of synapse development and plasticity by Rho GTPase regulatory proteins.A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invaginationRho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage
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P2860
The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth
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2002 nî lūn-bûn
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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2002 թվականի փետրվարին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
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2002年论文
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The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
@ast
The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
@en
The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
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type
label
The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
@ast
The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
@en
The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
@nl
prefLabel
The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
@ast
The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
@en
The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
@nl
P2093
P3181
P1433
P1476
The Human Rho-GEF trio and its ...... , leading to neurite outgrowth
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P2093
Anne Debant
Aubin Penna
Philippe Fort
Susanne Schmidt
Sylvie Diriong
P304
P3181
P356
10.1016/S0960-9822(02)00658-9
P407
P577
2002-02-19T00:00:00Z