Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain
about
sameAs
Novel Zn2+-binding Sites in Human Transthyretin: IMPLICATIONS FOR AMYLOIDOGENESIS AND RETINOL-BINDING PROTEIN RECOGNITIONMolecular basis for the Cu2+ binding-induced destabilization of beta2-microglobulin revealed by molecular dynamics simulation.Structure of the preamyloid dimer of beta-2-microglobulin from covalent labeling and mass spectrometry.Structural insights into the pre-amyloid tetramer of β-2-microglobulin from covalent labeling and mass spectrometryCu(II) organizes beta-2-microglobulin oligomers but is released upon amyloid formation.The effect of membranes on the in vitro fibrillation of an amyloidogenic light-chain variable-domain SMA.How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD.Copper binding to beta-2-microglobulin and its pre-amyloid oligomers.Unique effect of Cu(II) in the metal-induced amyloid formation of β-2-microglobulinSystemic amyloidoses.Formation of assemblies on cell membranes by secreted proteins: molecular studies of free λ light chain aggregates found on the surface of myeloma cells.Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils.Effect of amino acid mutations on the conformational dynamics of amyloidogenic immunoglobulin light-chains: A combined NMR and in silico study.Increase in the conformational flexibility of beta 2-microglobulin upon copper binding: a possible role for copper in dialysis-related amyloidosis.Serum albumin prevents protein aggregation and amyloid formation and retains chaperone-like activity in the presence of physiological ligands.Metal binding sheds light on mechanisms of amyloid assembly.Cu2+-induced modification of the kinetics of A beta(1-42) channels.Monoclonal light chain deposits within the stomach manifesting as immunotactoid gastropathy.A model for amyloid fibril formation in immunoglobulin light chains based on comparison of amyloidogenic and benign proteins and specific antibody binding.Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.A 19-year-old male with generalized seizures, unconsciousness and a deviation of gaze.Rheumatoid arthritis and renal light-chain deposition disease: long-term effectiveness of TNF-α blockade with etanercept.
P2860
Q27663605-9645CD2D-C8C2-4B5B-A97D-C084AA96B76DQ31033432-CA6662DD-8C52-4C6F-AA17-16A83FF4C9C1Q33765266-55BC744C-AB31-408C-AF81-3B2A8B0A1DA9Q35146213-8C41BE6B-2744-42A8-B223-2BD576BAAC95Q36503301-9C460817-293C-4247-AC51-DEB1000FBC25Q36915963-C9F64981-5B38-4308-9A20-C77F99F35269Q37045978-5B840C41-D608-4791-B0F9-C1EB13062F5CQ37398653-0AAFF9F3-CA53-4223-8D6F-4AEB6B248F17Q37701317-AD8BAEC1-EEC2-44FF-80CC-6ABBC5A1C507Q38085664-9472FC4E-4BB4-41A2-9378-611D786A862BQ39131174-A8FBDB06-6CDC-486D-B63B-063CBD166C4DQ40614534-2D87D814-B6ED-42AC-8D6F-9EB0499CCAB5Q41606174-D9511704-06D3-4DE6-AAA8-B848683339BDQ41849521-451CB42B-1AFB-4E7C-B4E9-F732BE9ECC32Q41858172-F910D5A7-4C0F-471A-89FA-2EF73926EF4CQ42123429-EC9BA7BB-3FD4-41EF-A4AF-8818A033C16AQ42601896-1882C940-551F-4EE0-8DA2-B6416C25A6EDQ46013698-819291A2-5E2C-4BFB-A93F-6C181624FE4BQ46016224-3DAB7059-C6EF-4A32-95E7-438BFAD2DFCBQ46426248-90896604-CB57-4F06-9E30-D368D300035CQ48499714-41014D02-BCC9-40A1-B6CE-D2738474D023Q53317870-5A99B188-1250-4710-A2AC-9C13AB7379CD
P2860
Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Both the environment and somat ...... nic immunoglobulin light chain
@ast
Both the environment and somat ...... nic immunoglobulin light chain
@en
Both the environment and somat ...... nic immunoglobulin light chain
@nl
type
label
Both the environment and somat ...... nic immunoglobulin light chain
@ast
Both the environment and somat ...... nic immunoglobulin light chain
@en
Both the environment and somat ...... nic immunoglobulin light chain
@nl
prefLabel
Both the environment and somat ...... nic immunoglobulin light chain
@ast
Both the environment and somat ...... nic immunoglobulin light chain
@en
Both the environment and somat ...... nic immunoglobulin light chain
@nl
P2093
P356
P1476
Both the environment and somat ...... nic immunoglobulin light chain
@en
P2093
F J Stevens
K L Sciarretta
P304
P356
10.1006/JMBI.2001.5092
P407
P577
2001-11-09T00:00:00Z