Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
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The Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationA novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradationNUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1RBR E3 ubiquitin ligases: new structures, new insights, new questionsAveraged differential expression for the discovery of biomarkers in the blood of patients with prostate cancerCalcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin.Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitinationParkin and relatives: the RBR family of ubiquitin ligases.The aggravating role of the ubiquitin-proteasome system in neurodegeneration.Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioningThe role of ubiquitin-protein ligases in neurodegenerative disease.The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates.Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast.The Lewy body in Parkinson's disease and related neurodegenerative disorders.RBR E3-ligases at workArchaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells.A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae.A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress.Porcine dorfin: molecular cloning of the RNF19 gene, sequence comparison, mapping and expression analysis.TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains.Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation.Repositioning Microtubule Stabilizing Drugs for Brain Disorders
P2860
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P2860
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@ast
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@en
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@nl
type
label
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@ast
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@en
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@nl
prefLabel
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@ast
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@en
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@nl
P2093
P3181
P356
P1476
Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
@en
P2093
Jun-Ichi Niwa
Manabu Doyu
Nozomi Hishikawa
Shinsuke Ishigaki
Takashi Ito
P304
P3181
P356
10.1074/JBC.M302763200
P407
P50
P577
2003-08-01T00:00:00Z