Oxidized neprilysin in aging and Alzheimer's disease brains
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beta-Amyloid degradation and Alzheimer's diseaseThe Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it?4-Hydroxy-nonenal-A Bioactive Lipid Peroxidation ProductClearance systems in the brain-implications for Alzheimer diseaseAmyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modificationThe role of magnesium deficiency in cardiovascular and intestinal inflammationEffect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation.Effects of 4-hydroxy-nonenal and Amyloid-beta on expression and activity of endothelin converting enzyme and insulin degrading enzyme in SH-SY5Y cells.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease.Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain.Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondriaAltered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease.N-acetylcysteine prevents 4-hydroxynonenal- and amyloid-beta-induced modification and inactivation of neprilysin in SH-SY5Y cellsDecreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease.Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid depositionCharacterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's diseaseAssociation between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome.Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's diseaseDesign of Peptide Substrate for Sensitively and Specifically Detecting Two Aβ-Degrading Enzymes: Neprilysin and Angiotensin-Converting Enzyme.Microglial Inhibitory Mechanism of Coenzyme Q10 Against Aβ (1-42) Induced Cognitive Dysfunctions: Possible Behavioral, Biochemical, Cellular, and Histopathological Alterations.Neprilysin: an enzyme candidate to slow the progression of Alzheimer's diseasePolyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease.Distinct subcellular patterns of neprilysin protein and activity in the brains of Alzheimer's disease patients, transgenic mice and cultured human neuronal cells.Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells.Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemiaNeprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's DiseaseActivation of proinflammatory signaling by 4-hydroxynonenal-Src adducts in aged kidneys.Aspects of beta-amyloid as a biomarker for Alzheimer's disease.Elevation of glutathione as a therapeutic strategy in Alzheimer disease.Proteolytic degradation of amyloid β-protein.Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease.Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications.Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, anWhite matter hypoperfusion and damage in dementia: post-mortem assessment.Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines.HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytesAggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer's disease: a stochastic modelling approach.Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice.Neprylisin decreases uniformly in Alzheimer's disease and in normal aging.
P2860
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P2860
Oxidized neprilysin in aging and Alzheimer's disease brains
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Oxidized neprilysin in aging and Alzheimer's disease brains
@ast
Oxidized neprilysin in aging and Alzheimer's disease brains
@en
Oxidized neprilysin in aging and Alzheimer's disease brains
@nl
type
label
Oxidized neprilysin in aging and Alzheimer's disease brains
@ast
Oxidized neprilysin in aging and Alzheimer's disease brains
@en
Oxidized neprilysin in aging and Alzheimer's disease brains
@nl
prefLabel
Oxidized neprilysin in aging and Alzheimer's disease brains
@ast
Oxidized neprilysin in aging and Alzheimer's disease brains
@en
Oxidized neprilysin in aging and Alzheimer's disease brains
@nl
P2093
P3181
P1476
Oxidized neprilysin in aging and Alzheimer's disease brains
@en
P2093
Deng-Shun Wang
Nobuhisa Iwata
Takaomi C Saido
P304
P3181
P356
10.1016/J.BBRC.2003.09.003
P407
P577
2003-10-10T00:00:00Z