Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
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Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosisErythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathwayBromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genesPIG-A mutations in paroxysmal nocturnal hemoglobinuria and in normal hematopoiesisETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cellsMegakaryocytic programming by a transcriptional regulatory loop: A circle connecting RUNX1, GATA-1, and P-TEFb.The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesisDifferential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and developmentDistinctive hematological abnormalities in East Asian neonates and children with Down syndrome.The prenatal origins of cancerGATA1 function, a paradigm for transcription factors in hematopoiesisRepression of c-kit and its downstream substrates by GATA-1 inhibits cell proliferation during erythroid maturationGATA1-mediated megakaryocyte differentiation and growth control can be uncoupled and mapped to different domains in GATA1Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder.Identification of distinct molecular phenotypes in acute megakaryoblastic leukemia by gene expression profiling.Effect of transcription-factor concentrations on leukemic stem cells.Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model.Origins of leukaemia in children with Down syndrome.Vitamin supplement use among children with Down's syndrome and risk of leukaemia: a Children's Oncology Group (COG) studyMechanisms of thrombopoiesis.Optimizing therapy for myeloid disorders of Down syndrome.Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndromeMyeloid Proliferations Associated with Down Syndrome.Down syndrome and acute lymphoblastic leukaemia.Trisomy 21 enhances human fetal erythro-megakaryocytic development.Unbalanced chromosome 1 abnormalities leading to partial trisomy 1q in four infants with Down syndrome and acute megakaryocytic leukemiaGATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorderMalignancy in children with trisomy 21.Leukemogenesis caused by incapacitated GATA-1 function.Transient leukemia in a newborn without Down syndrome: case report and review of the literature.Advances in understanding the pathogenesis of congenital erythropoietic porphyria.Fetal liver stromal cells support blast growth in transient abnormal myelopoiesis in Down syndrome through GM-CSF.Distinct GATA1 Point Mutations in Monozygotic Twins With Down Syndrome and Transient Abnormal Myelopoiesis From a Triplet Pregnancy: A Case Report and Review of Literature.Treatment for myeloid leukaemia of Down syndrome: population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials.Graded levels of GATA-1 expression modulate survival, proliferation, and differentiation of erythroid progenitors.Notch1-mediated signaling induces MHC class II expression through activation of class II transactivator promoter III in mast cells.Apoptosis in Down's syndrome: lessons from studies of human and mouse models.Acute megakaryoblastic leukemia associated with trisomy 21 demonstrates a distinct immunophenotype.Transient myeloproliferative disorder and eosinophilic pericardial effusion in a down syndrome neonate.
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P2860
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@ast
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@en
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@nl
type
label
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@ast
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@en
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@nl
prefLabel
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@ast
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@en
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@nl
P1433
P1476
Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome
@en
P2093
Sandeep Gurbuxani
P304
P356
10.1182/BLOOD-2003-05-1556
P407
P577
2004-01-15T00:00:00Z