Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole
about
sameAs
MALDI-tandem mass spectrometry imaging of astemizole and its primary metabolite in rat brain sections.Immunochemical detection of cytochrome P450 enzymes in small intestine microsomes of male and female untreated juvenile cynomolgus monkeysInvestigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo.Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function.Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance.Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine.Variability of CYP2J2 expression in human fetal tissues.Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activityThe human intestinal cytochrome P450 "pie".Unusual regioselectivity and active site topology of human cytochrome P450 2J2Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes.Cytochrome P450 reaction-phenotyping: an industrial perspective.Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayersActivity, inhibition, and induction of cytochrome P450 2J2 in adult human primary cardiomyocytes.Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity.Editor's Highlight: Transgenic Zebrafish Reporter Lines as Alternative In Vivo Organ Toxicity Models.Drug and xenobiotic biotransformation in the blood-brain barrier: a neglected issue.PharmGKB summary: cytochrome P450, family 2, subfamily J, polypeptide 2: CYP2J2.In vitro inhibition of human small intestinal and liver microsomal astemizole O-demethylation: different contribution of CYP2J2 in the small intestine and liver.Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies.Marmoset cytochrome P450 2J2 mainly expressed in small intestines and livers effectively metabolizes human P450 2J2 probe substrates, astemizole and terfenadine.CYP2J2 expression in adult ventricular myocytes protects against external and drug induced ROS toxicity.Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds.Extrahepatic Drug-Metabolizing Enzymes and Their SignificanceInter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations
P2860
Q33748863-A7BA9630-A9B3-401F-80B8-4A1ACB4A612FQ33915133-FB773244-F81A-4F22-B11E-E7047936EB26Q34217770-619174F1-4DA4-4D81-B611-BFF6E41E6BF0Q34273354-C3829994-E830-494C-9170-55F3BA025B90Q34358307-0B0B7731-F5D2-4F6D-8852-A6912927C75CQ34959269-46546C69-2547-4C4B-A774-0915511FE3C1Q35809421-44C2E536-5750-42F1-8C7D-4EE0EC42B3CCQ35809450-4771898C-14F7-4863-9295-8FFD580E8C59Q35913099-58B8C570-135B-4254-9B7D-129C743DE2E5Q36420382-799E4923-1688-4B73-8563-4233022C3079Q36648643-8BAA49F3-F92F-4D32-8242-D911039DF776Q36947747-9A24E175-7097-48EB-A91E-4B3BE2D5EF71Q36960539-6257DC77-56BD-4133-AA2E-AEFCE8F9C8E4Q37034584-8F9BB429-4E02-4540-A8B5-604CD6335CB8Q37325576-B5F4CDC8-598B-403A-B430-845FA8C524A3Q37386629-4866C930-7288-4EED-BA1E-8FD15E2A345CQ37845170-2C302CC2-99BE-4337-AA5B-10E44337A203Q39030456-0C51C931-C11E-4456-8C03-732A7A7A6CA5Q39103468-10C66D8B-92E7-4A7B-8490-7E0685BDD027Q41764712-2B3EDFE5-1FF5-4499-8426-F1ED0C1F00DEQ44506708-7D6416B5-FDBF-4256-85CC-7356C3B688C0Q48234194-8C0B9957-B766-4E1A-BE06-389E4A90A434Q48889351-A9DFEF36-25CF-4691-AA5C-A67493AA2DE6Q49989932-5B47C10F-9096-46D1-88AA-D84E22AFD0E3Q50534856-FEC54D7E-7DFD-45E0-94CE-2F8DF6C93C22Q57258718-D82CBABD-0EF2-4378-958F-CE7294377FACQ59153131-054C8D81-0BF3-4287-9A17-F9900F11431D
P2860
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@ast
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@en
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@nl
type
label
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@ast
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@en
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@nl
prefLabel
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@ast
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@en
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@nl
P2093
P356
P1476
Involvement of CYP2J2 on the i ...... antihistamine drug, astemizole
@en
P2093
Kiyoshi Nagata
Shigeki Matsumoto
Tomoe Hirama
Tsutomu Matsubara
Yasushi Yamazoe
P304
P356
10.1124/DMD.30.11.1240
P407
P577
2002-11-01T00:00:00Z