Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
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Sirtuins: Sir2-related NAD-dependent protein deacetylasesEnzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promotersInvolvement of SIRT7 in resumption of rDNA transcription at the exit from mitosisStructural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylasesInvolvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repressionSirtuin functions and modulation: from chemistry to the clinicEpigenetic associations in relation to cardiovascular prevention and therapeuticsThe role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectivesProtective effects and mechanisms of sirtuins in the nervous systemChemical probes in plant epigenetics studiesLysine deacetylase (KDAC) regulatory pathways: an alternative approach to selective modulationStructural basis for the NAD-dependent deacetylase mechanism of Sir2Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismMultiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological ImplicationsThe role of sirtuins in cellular homeostasisThe promise and perils of HDAC inhibitors in neurodegenerationConserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylasesIdentification of a small molecule inhibitor of Sir2pPlumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cellsSchistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targetsComputational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicalsCambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective propertiesResveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathwaySIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neuronsThe Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae.Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells.Rejuvenating sirtuins: the rise of a new family of cancer drug targetsA potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease.Considerations for designing chemical screening strategies in plant biology.A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression.Recruitment to the nuclear periphery can alter expression of genes in human cells.Sirtinol, a Sir2 protein inhibitor, affects stem cell maintenance and root development in Arabidopsis thaliana by modulating auxin-cytokinin signaling components.Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activityChemical genetic dissection of brassinosteroid-ethylene interactionSirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2.SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells.Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling.
P2860
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P2860
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification of a class of s ...... ylases by phenotypic screening
@ast
Identification of a class of s ...... ylases by phenotypic screening
@en
Identification of a class of s ...... ylases by phenotypic screening
@nl
type
label
Identification of a class of s ...... ylases by phenotypic screening
@ast
Identification of a class of s ...... ylases by phenotypic screening
@en
Identification of a class of s ...... ylases by phenotypic screening
@nl
prefLabel
Identification of a class of s ...... ylases by phenotypic screening
@ast
Identification of a class of s ...... ylases by phenotypic screening
@en
Identification of a class of s ...... ylases by phenotypic screening
@nl
P2093
P3181
P356
P1476
Identification of a class of s ...... ylases by phenotypic screening
@en
P2093
C M Grozinger
H E Blackwell
S L Schreiber
P304
P3181
P356
10.1074/JBC.M106779200
P407
P577
2001-10-19T00:00:00Z