The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization
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An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamicsProtein kinase A regulates AKAP250 (gravin) scaffold binding to the beta2-adrenergic receptorDifferential and regulated binding of cAMP-dependent protein kinase and protein kinase C isoenzymes to gravin in human model neurons: Evidence that gravin provides a dynamic platform for the localization for kinases during neuronal developmentNetworking with AKAPs: context-dependent regulation of anchored enzymesAKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptorbeta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to GiAKAP signalling complexes: focal points in space and timeConfinement of β(1)- and β(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae.Effects of progesterone treatment on expression of genes involved in uterine quiescence.AKAR2-AKAP12 fusion protein "biosenses" dynamic phosphorylation and localization of a GPCR-based scaffold.pp60Src mediates insulin-stimulated sequestration of the beta(2)-adrenergic receptor: insulin stimulates pp60Src phosphorylation and activation.Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.Enhanced cardiac function in Gravin mutant mice involves alterations in the β-adrenergic receptor signaling cascadeAKAP5 and AKAP12 Form Homo-oligomers.AKAP12 and AKAP5 form higher-order hetero-oligomers.Yeast Ste2 receptors as tools for study of mammalian protein kinases and adaptors involved in receptor trafficking.AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexes.Protein-protein interactions at the adrenergic receptors."Shaping" of cell signaling via AKAP-tethered PDE4D: Probing with AKAR2-AKAP5 biosensor.Inherited disposition to cardiac myxoma development.Regulation of g protein-coupled receptor signaling by a-kinase anchoring proteins.G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential signaling to MAPK and GPCR recycling.Supramolecular assemblies and localized regulation of voltage-gated ion channels.Fine-tuning of GPCR activity by receptor-interacting proteinsPromotion and inhibition of cardiac hypertrophy by A-kinase anchor proteins.A macromolecular trafficking complex composed of β₂-adrenergic receptors, A-Kinase Anchoring Proteins and L-type calcium channels.Minireview: Role of intracellular scaffolding proteins in the regulation of endocrine G protein-coupled receptor signaling.Receptor-mediated Ca2+ and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin.Gravin dynamics regulates the subcellular distribution of PKA.Lysophosphatidic acid regulates trafficking of beta2-adrenergic receptors: the Galpha13/p115RhoGEF/JNK pathway stimulates receptor internalization.Src docks to A-kinase anchoring protein gravin, regulating beta2-adrenergic receptor resensitization and recycling.Regulation of AKAP-membrane interactions by calcium.Development of platelet inhibition by cAMP during megakaryocytopoiesis.Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channelsNon-invasive Optical Biosensor for Probing Cell Signaling.Priming GPCR signaling through the synergistic effect of two G proteins.Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders.Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice.Roles of A-Kinase Anchoring Proteins and Phosphodiesterases in the Cardiovascular System.
P2860
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P2860
The scaffold protein gravin (cAMP-dependent protein kinase-anchoring protein 250) binds the beta 2-adrenergic receptor via the receptor cytoplasmic Arg-329 to Leu-413 domain and provides a mobile scaffold during desensitization
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The scaffold protein gravin (c ...... caffold during desensitization
@ast
The scaffold protein gravin (c ...... caffold during desensitization
@en
The scaffold protein gravin (c ...... caffold during desensitization
@nl
type
label
The scaffold protein gravin (c ...... caffold during desensitization
@ast
The scaffold protein gravin (c ...... caffold during desensitization
@en
The scaffold protein gravin (c ...... caffold during desensitization
@nl
prefLabel
The scaffold protein gravin (c ...... caffold during desensitization
@ast
The scaffold protein gravin (c ...... caffold during desensitization
@en
The scaffold protein gravin (c ...... caffold during desensitization
@nl
P2093
P2860
P356
P1476
The scaffold protein gravin (c ...... caffold during desensitization
@en
P2093
P2860
P304
P356
10.1074/JBC.M011199200
P407
P577
2001-06-29T00:00:00Z