Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase
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The serine/threonine kinase Nek6 is required for cell cycle progression through mitosisNek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responsesA mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinasesThe NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formationNek6 is involved in G2/M phase cell cycle arrest through DNA damage-induced phosphorylationMitotic regulation by NIMA-related kinasesMutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progressionRegulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation siteNovel cross talk between MEK and S6K2 in FGF-2 induced proliferation of SCLC cellsMolecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivoMultiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase BPDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle."Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinasesRole of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6The Nek2 protein kinase: a novel regulator of centrosome structure.C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma.Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma.Mammalian TOR signaling to the AGC kinases.Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6.Nek family of kinases in cell cycle, checkpoint control and cancer.Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction.P70 S6 kinase mediates tau phosphorylation and synthesis.Akt2, a novel functional link between p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in myogenesis.Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex.Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling.A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.NEK7 is required for G1 progression and procentriole formation.Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation.Mitotic regulation of ribosomal S6 kinase 1 involves Ser/Thr, Pro phosphorylation of consensus and non-consensus sites by Cdc2.M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.Mitotic Regulation by NEK Kinase Networks.Regulation of Nek6 functions by its SUMOylation on the K252residue
P2860
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P2860
Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@ast
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@en
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@nl
type
label
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@ast
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@en
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@nl
prefLabel
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@ast
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@en
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@nl
P2093
P1433
P1476
Identification of the NIMA fam ...... of the p70 ribosomal S6 kinase
@en
P2093
P304
P356
10.1016/S0960-9822(01)00369-4
P407
P577
2001-08-07T00:00:00Z