S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
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An overview of Cdk1-controlled targets and processesDisruption of mechanisms that prevent rereplication triggers a DNA damage responseCDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeastHow do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeastSaccharomyces cerevisiae DNA polymerase epsilon and polymerase sigma interact physically and functionally, suggesting a role for polymerase epsilon in sister chromatid cohesionSld2 binds to origin single-stranded DNA and stimulates DNA annealing.Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase.A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11Efficient initiation of DNA replication in eukaryotes requires Dpb11/TopBP1-GINS interactionSld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast.Dpb11, the budding yeast homolog of TopBP1, functions with the checkpoint clamp in recombination repairOrdered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins.DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6Control of cell cycle transcription during G1 and S phasesMathematical modelling of DNA replication reveals a trade-off between coherence of origin activation and robustness against rereplicationTargets of the cyclin-dependent kinase Cdk1Cell cycle regulation by feed-forward loops coupling transcription and phosphorylationA comprehensive molecular interaction map of the budding yeast cell cycle.Role of the p68 subunit of human DNA polymerase alpha-primase in simian virus 40 DNA replicationDe novo assembly of genuine replication forks on an immobilized circular plasmid in Xenopus egg extracts.The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiationInteraction of the S-phase cyclin Clb5 with an "RXL" docking sequence in the initiator protein Orc6 provides an origin-localized replication control switch.Swe1 regulation and transcriptional control restrict the activity of mitotic cyclins toward replication proteins in Saccharomyces cerevisiae.Control of DNA replication by cyclin-dependent kinases in developmentMultiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance.Method for identifying phosphorylated substrates of specific cyclin/cyclin-dependent kinase complexes.Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progressionMcm10 plays an essential role in origin DNA unwinding after loading of the CMG componentsDNA polymerization-independent functions of DNA polymerase epsilon in assembly and progression of the replisome in fission yeastIdentifying responsive modules by mathematical programming: an application to budding yeast cell cycle.Control of DNA replication licensing in a cell cycle.MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replicationCyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation.Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins.Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replicationEukaryotic MCM proteins: beyond replication initiation.
P2860
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P2860
S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast
description
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Nature
@fr
artículu científicu espublizáu en 2002
@ast
scientific article (publication date: 7 February 2002)
@en
vedecký článok (publikovaný 2002/02/07)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/02/07)
@nl
наукова стаття, опублікована в лютому 2002
@uk
مقالة علمية (نشرت في 7-2-2002)
@ar
name
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@ast
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@en
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@nl
type
label
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@ast
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@en
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@nl
prefLabel
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@ast
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@en
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@nl
P2093
P356
P1433
P1476
S-Cdk-dependent phosphorylatio ...... A replication in budding yeast
@en
P2093
Hiroshi Masumoto
Hiroyuki Araki
Sachiko Muramatsu
Yoichiro Kamimura
P2888
P356
10.1038/NATURE713
P407
P577
2002-02-07T00:00:00Z
P6179
1049620350