about
The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathwayRelief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomasSH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerLocal phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migrationAllostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signalsInterlobular and intralobular mammary stroma: genotype may not reflect phenotypeAssembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric controlRasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.Noonan syndrome: clinical aspects and molecular pathogenesis.Engineered single nucleotide polymorphisms in the mosquito MEK docking site alter Plasmodium berghei development in Anopheles gambiae.Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanismsNoonan syndrome and clinically related disorders.SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlationsRegulation of Neuronal Function by Ras-GRF Exchange Factors.CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.Transcriptional hallmarks of Noonan syndrome and Noonan-like syndrome with loose anagen hair.Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome.Hereditary gingival fibromatosis: characteristics and novel putative pathogenic mechanisms.Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factorActivation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization.Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.Tumor adaptation and resistance to RAF inhibitors.Phosphatidylinositol 3-kinase activation is required to form the NKG2D immunological synapse.MiR-148a impairs Ras/ERK signaling in B lymphocytes by targeting SOS proteinsDeciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins.Internal driving factors leading to extrahepatic manifestation of the hepatitis C virus infection.M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1.MicroRNA 628 suppresses migration and invasion of breast cancer stem cells through targeting SOS1
P2860
Q24298005-3EBAA5F2-1579-4001-8F3F-EF0C46CFE5EAQ24303940-4CA354DB-492E-403F-A7C3-D644489DBC45Q24309634-F6F3A529-20AB-41E8-A645-F1861F0B37BAQ28567890-A210EBCD-E8CF-4504-BFAB-E63031B38981Q28579777-36C73533-5F4E-4C45-9D17-EE153DE2AC36Q30009939-2734496E-E4EE-4F32-AA4E-B84783E76228Q30157067-C969B411-FFD2-4FDF-B6B1-34421D17480CQ33361045-3B175499-5C6B-49E1-B096-BC4FD9F93E4EQ33643185-F425FDCF-1868-434E-82D2-E4B2D01AE5E1Q33720198-46E15F43-BBA5-4593-A372-DA1253CBFACDQ33806161-A2F9D80E-E97E-4A04-A634-4823AE5F844DQ33830233-C4C72A59-E6C9-4D9C-B120-91292C957AF4Q34360215-543A24BF-275B-4BD2-849F-E1C95DB3CE94Q34440570-24466270-56F5-4B26-8FFD-67F24DBC94B2Q34678373-22034FC0-E4E6-4E55-9F9B-41A851547FE5Q35056507-086DD680-E3B6-4CF6-88C7-2C1BF6DDDC15Q35083736-CB141C00-15CA-4F7F-B26B-C833C88C17AEQ35503875-7656F45D-8000-4CB9-99B1-98B1F9D307FCQ35829938-2B244265-0BAB-4E49-B0D1-6C91E9900F49Q35903618-2BF0191C-56B3-44E6-B3F7-ABE5D7D34922Q36157128-F463D956-C6D1-4176-86E0-CBBC8BD267F4Q36692626-20458A37-3986-4671-A63B-87AD9562B4A9Q36736139-32DADD15-42C2-472C-A8D0-D05B9F7F6F7BQ36978232-F60423DA-17D7-4029-939B-F3AD51C146AAQ37113976-A67BC99B-9187-44B1-AA21-DD2AC79022C9Q37529620-75525853-CC91-4FF2-A281-3EE1072E5FD5Q38136655-C5637015-6BE4-449A-9D81-5B480D464BADQ38160738-76D067E8-006F-4DEE-815E-819630C96B8BQ40070389-9FD884AD-87F6-4E3D-A934-AE21327A4A5AQ41346414-5C4339C4-FE84-40B8-B5CC-424119F31D37Q42158425-ABCF1675-87F6-4684-A444-DCB861819028Q42516966-357D0897-9E31-45DE-999E-91E8DDD52564Q47697362-3205D0D0-A47B-4889-BE9F-832774B2A26FQ58764982-645CB1B3-B6B8-4B53-9B37-86C3A29C0F80
P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The two hats of SOS
@ast
The two hats of SOS
@en
The two hats of SOS
@nl
type
label
The two hats of SOS
@ast
The two hats of SOS
@en
The two hats of SOS
@nl
altLabel
The Two Hats of SOS
@en
prefLabel
The two hats of SOS
@ast
The two hats of SOS
@en
The two hats of SOS
@nl
P2860
P1476
The Two Hats of SOS
@en
The two hats of SOS
@en
P2093
A. Nimnual
Anjaruwee Nimnual
P2860
P356
10.1126/SCISIGNAL.1452002PE36
10.1126/STKE.2002.145.PE36
P407
P577
2002-08-13T00:00:00Z