Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
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Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairProtein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damageCheckpoint recovery in cells: how a molecular understanding can help in the fight against cancerPPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsOncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathwayp38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanismsBiological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspectiveThe HBP1 transcriptional repressor participates in RAS-induced premature senescenceNovel hepatocellular carcinoma molecules with prognostic and therapeutic potentialsWip-ing out cancerRegulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphataseRole of mitogen-activated protein kinase kinase 4 in cancerMosaic PPM1D mutations are associated with predisposition to breast and ovarian cancerThe effects of chromium(VI) on the thioredoxin system: implications for redox regulationWip1 suppresses ovarian cancer metastasis through the ATM/AKT/Snail mediated signalingWee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapyMAP kinase signalling pathways in cancerAnticancer effect of Tamarix gallica extracts on human colon cancer cells involves Erk1/2 and p38 action on G2/M cell cycle arrest.Dysregulated estrogen receptor signaling in the hypothalamic-pituitary-ovarian axis leads to ovarian epithelial tumorigenesis in miceA high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts.A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.Retinoblastoma loss modulates DNA damage response favoring tumor progressionThe oncogenic phosphatase WIP1 negatively regulates nucleotide excision repairExcitability in the p53 network mediates robust signaling with tunable activation thresholds in single cellsProgesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase.Phosphatases reverse p53-mediated cell cycle checkpointsThe mitogen-activated protein (MAP) kinases p38 and extracellular signal-regulated kinase (ERK) are involved in hepatocyte-mediated phenotypic switching in prostate cancer cellsTranscriptional response of lymphoblastoid cells to ionizing radiationInactivation of p38 MAPK contributes to stem cell-like properties of non-small cell lung cancerWIP1 phosphatase as pharmacological target in cancer therapy.Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.Stress signaling and the shaping of the mammary tissue in development and cancer.Posttranslational modification of p53: cooperative integrators of functionAbnormality of pl6/p38MAPK/p53/Wipl pathway in papillary thyroid cancerWip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage responsep38α MAPK pathway: a key factor in colorectal cancer therapy and chemoresistance.Progenitor-derived hepatocellular carcinoma model in the rat.
P2860
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P2860
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@ast
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@en
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@nl
type
label
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@ast
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@en
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@nl
prefLabel
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@ast
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@en
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@nl
P2093
P50
P3181
P356
P1433
P1476
Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
@en
P2093
Angel R Nebreda
Carl W Anderson
Concetta Ambrosino
Crissy Phillips
Dmitry V Bulavin
Guido Sauter
Paivikki Kauraniemi
Sally A Amundson
Shin'ichi Saito
P2888
P3181
P356
10.1038/NG894
P407
P577
2002-06-01T00:00:00Z