Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome
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Deadly allies: the fatal interplay between platelets and metastasizing cancer cellsThe contribution of mouse models to the understanding of constitutional thrombocytopeniaLinkage between the mechanisms of thrombocytopenia and thrombopoiesisNovel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition.A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and functionBernard-Soulier syndromeThe role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.Inflammation induces hemorrhage in thrombocytopenia.Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interactionRed blood cells mediate the onset of thrombosis in the ferric chloride murine model.Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation.Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis.Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice.In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation.Synthesis of GPIb beta with novel transmembrane and cytoplasmic sequences in a Bernard-Soulier patient resulting in GPIb-defective signaling in CHO cells.Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhageThe maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies.Correction of murine Bernard-Soulier syndrome by lentivirus-mediated gene therapy.Platelets with a W127X mutation in GPIX express sufficient residual amounts of GPIbα to support adhesion to von Willebrand factor and collagen.Platelet ITAM signaling is critical for vascular integrity in inflammation.Pathogenesis and management of inherited thrombocytopenias: rationale for the use of thrombopoietin-receptor agonists.Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortality.Lessons in platelet production from inherited thrombocytopenias.Adoptive transfer method to study platelet function in mouse models of disease.Dimerization of glycoprotein Ibα is not sufficient to induce platelet clearance.Inherited thrombocytopenias-recent advances in clinical and molecular aspects.A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivovon Willebrand factor: an emerging target in stroke therapy.Megakaryocytes and beyond: the birth of platelets.Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.The organizing principle of the platelet glycoprotein Ib-IX-V complex.Platelet glycoprotein Ib beta/IX mediates glycoprotein Ib alpha localization to membrane lipid domain critical for von Willebrand factor interaction at high shearPlatelet glycoprotein Ibα is an important mediator of ischemic stroke in mice.Cellular fibronectin containing extra domain A promotes arterial thrombosis in mice through platelet Toll-like receptor 4Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17)von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veinsPlatelet glycoprotein Ib alpha supports experimental lung metastasisGPIbα regulates platelet size by controlling the subcellular localization of filamin
P2860
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P2860
Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@ast
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@en
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@nl
type
label
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@ast
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@en
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@nl
prefLabel
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@ast
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@en
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@nl
P2093
P3181
P1433
P1476
Amelioration of the macrothrom ...... urine Bernard-Soulier syndrome
@en
P2093
Jerry Ware
Susan Russell
Taisuke Kanaji
P304
P3181
P356
10.1182/BLOOD-2002-03-0997
P407
P577
2002-09-15T00:00:00Z