Structure and molecular organization of mammalian fatty acid synthase
about
Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopyCrystal structure of the thioesterase domain of human fatty acid synthase inhibited by OrlistatMode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI InhibitorA human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate siteUsing modern tools to probe the structure-function relationship of fatty acid synthasesArchitecture of the polyketide synthase module: surprises from electron cryo-microscopyConformational flexibility of metazoan fatty acid synthase enables catalysisMass spectrometry-based systems approach for identification of inhibitors of Plasmodium falciparum fatty acid synthaseBiosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase.Structural enzymology of polyketide synthases.Expression of fatty acid synthase in nonalcoholic fatty liver disease.Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells.Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker.cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells.Probing intra- versus interchain kinetic preferences of L-Thr acylation on dimeric VibF with mass spectrometry.Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthaseThe 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis.Efficacy of massage therapy on pain and dysfunction in patients with neck pain: a systematic review and meta-analysis.Fatty acid synthase as a potential therapeutic target in cancer.FASN and CD36 predict survival in rituximab-treated diffuse large B-cell lymphoma.Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASEFatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors.Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs.Gold nanoparticle-protein arrays improve resolution for cryo-electron microscopy.The type I fatty acid and polyketide synthases: a tale of two megasynthasesFatty acid synthase is a novel therapeutic target in multiple myeloma.Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feedingFatty acid synthase inhibitors: new directions for oncology.Polyketides in insects: ecological role of these widespread chemicals and evolutionary aspects of their biogenesis.Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteinsStructural analysis of protein-protein interactions in type I polyketide synthasesMiR-30c-5p ameliorates hepatic steatosis in leptin receptor-deficient (db/db) mice via down-regulating FASN.Structure and function of eukaryotic fatty acid synthases.Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs.Safety, tolerability and pharmacokinetics of AFN-1252 administered as immediate release tablets in healthy subjects.Clove extract functions as a natural fatty acid synthesis inhibitor and prevents obesity in a mouse model.Bacterial fatty acid metabolism in modern antibiotic discovery.Crystallization and preliminary X-ray diffraction analysis of FabG from Yersinia pestis.
P2860
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P2860
Structure and molecular organization of mammalian fatty acid synthase
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structure and molecular organization of mammalian fatty acid synthase
@ast
Structure and molecular organization of mammalian fatty acid synthase
@en
Structure and molecular organization of mammalian fatty acid synthase
@nl
type
label
Structure and molecular organization of mammalian fatty acid synthase
@ast
Structure and molecular organization of mammalian fatty acid synthase
@en
Structure and molecular organization of mammalian fatty acid synthase
@nl
prefLabel
Structure and molecular organization of mammalian fatty acid synthase
@ast
Structure and molecular organization of mammalian fatty acid synthase
@en
Structure and molecular organization of mammalian fatty acid synthase
@nl
P2093
P2860
P356
P1476
Structure and molecular organization of mammalian fatty acid synthase
@en
P2093
Andrzej Witkowski
Anil K Joshi
Francisco J Asturias
Helga Stark
Iris K Cheung
James Z Chadick
Stuart Smith
P2860
P2888
P304
P356
10.1038/NSMB899
P407
P577
2005-03-01T00:00:00Z
P5875
P6179
1032967129