Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
about
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2bγ-Secretase inhibitors and modulators.Toward the structure of presenilin/γ-secretase and presenilin homologsPlasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesisComplex regulation of γ-secretase: from obligatory to modulatory subunitsSignal peptide peptidase is required for dislocation from the endoplasmic reticulumGamma-secretase complex assembly within the early secretory pathwayA C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysisDifferential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase InhibitorsCellular functions of gamma-secretase-related proteins.γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide PeptidaseFunctional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Drosophila signal peptide peptidase is an essential protease for larval development.Three-dimensional structure of the signal peptide peptidaseVigilin interacts with signal peptide peptidase.Preprocalcitonin signal peptide generates a cytotoxic T lymphocyte-defined tumor epitope processed by a proteasome-independent pathwaySignal peptide peptidases and gamma-secretase: cousins of the same protease family?Distinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase.Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents.Intramembrane proteolysisPresenilins: members of the gamma-secretase quartets, but part-time soloists too.Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generationThe Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins.The structure and function of Alzheimer's gamma secretase enzyme complex.Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes.Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes.C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.Development of clickable active site-directed photoaffinity probes for γ-secretase.A misassembled transmembrane domain of a polytopic protein associates with signal peptide peptidase.Insights into the mechanism of isoenzyme-specific signal peptide peptidase-mediated translocation of heme oxygenase.Solution Structure of an Intramembrane Aspartyl Protease via Small Angle Neutron Scattering.Lessons from an α-Helical Membrane Enzyme: Expression, Purification, and Detergent Optimization for Biophysical and Structural Characterization.
P2860
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P2860
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@ast
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@en
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@nl
type
label
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@ast
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@en
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@nl
prefLabel
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@ast
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@en
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@nl
P2093
P356
P1476
Signal peptide peptidase forms ...... cted gamma-secretase inhibitor
@en
P2093
Andrew C Nyborg
Anna Y Kornilova
Karen Jansen
Michael S Wolfe
Thomas B Ladd
Todd E Golde
P304
P356
10.1074/JBC.M309305200
P407
P577
2004-04-09T00:00:00Z