Copper is required for oncogenic BRAF signalling and tumorigenesis - Wikidata - wikimedia - TriplyDB

Copper is required for oncogenic BRAF signalling and tumorigenesis

Copper is required for oncogenic BRAF signalling and tumorigenesis

http://www.wikidata.org/entity/Q28237892

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Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma Beyond BRAF: where next for melanoma therapy?Synthetic fluorescent probes for studying copper in biological systems New silver nanoparticles induce apoptosis-like process in E. coli and interfere with mammalian copper metabolism Copper regulates cyclic-AMP-dependent lipolysis KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents.Roles of Copper-Binding Proteins in Breast Cancer.Natural variations of copper and sulfur stable isotopes in blood of hepatocellular carcinoma patients.Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S.Communication between the N and C termini is required for copper-stimulated Ser/Thr phosphorylation of Cu(I)-ATPase (ATP7B).Pharmacological activity of metal binding agents that alter copper bioavailability.Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition.Recognition- and reactivity-based fluorescent probes for studying transition metal signaling in living systems.Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.The Features of Copper Metabolism in the Rat Liver during Development The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).Copper Uptake in Mammary Epithelial Cells Activates Cyclins and Triggers Antioxidant Response Phospholipid binding to the FAK catalytic domain impacts function.Cisplatin inhibits MEK1/2.The Emerging Hallmarks of Cancer Metabolism Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H2O2 generation: antagonism by tetrathiomolybdate.Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy.Methanobactin and the Link between Copper and Bacterial Methane Oxidation ERK2 phosphorylates Krüppel-like factor 8 protein at serine 48 to maintain its stability.Transcriptome analysis of copper homeostasis genes reveals coordinated upregulation of SLC31A1,SCO1, and COX11 in colorectal cancer.Bivalent Copper Ions Promote Fibrillar Aggregation of KCTD1 and Induce Cytotoxicity In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease.Dextran-Catechin: An anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth Genetic variants in ABCG1 are associated with survival of nonsmall-cell lung cancer patients.Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells.Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway.Cuprous oxide nanoparticles inhibit prostate cancer by attenuating the stemness of cancer cells via inhibition of the Wnt signaling pathway.Emerging roles of metal solute carriers in cancer mechanisms and treatment.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Targeting copper in cancer therapy: 'Copper That Cancer'.Downregulation of hepatic multi-drug resistance protein 1 (MDR1) after copper exposure.Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines.Filamin A (FLNA) modulates chemosensitivity to docetaxel in triple-negative breast cancer through the MAPK/ERK pathway.Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

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P2860

Copper is required for oncogenic BRAF signalling and tumorigenesis

http://www.wikidata.org/entity/Q28237892

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Copper is required for oncogenic BRAF signalling and tumorigenesis

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Copper is required for oncogenic BRAF signalling and tumorigenesis

@en

Copper is required for oncogenic BRAF signalling and tumorigenesis

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type

label

Copper is required for oncogenic BRAF signalling and tumorigenesis

@ast

Copper is required for oncogenic BRAF signalling and tumorigenesis

@en

Copper is required for oncogenic BRAF signalling and tumorigenesis

@nl

prefLabel

Copper is required for oncogenic BRAF signalling and tumorigenesis

@ast

Copper is required for oncogenic BRAF signalling and tumorigenesis

@en

Copper is required for oncogenic BRAF signalling and tumorigenesis

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Copper is required for oncogenic BRAF signalling and tumorigenesis

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Christopher M Counter

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Dennis J Thiele

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Donita C Brady

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Kunhong Xiao

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Matthew S Crowe

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Michelle L Turski

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Sharon L Campbell

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Xiaojie Yao

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P2860

The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors

Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling.

Mutations of the BRAF gene in human cancer

Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control

Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake

Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

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492-496

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10.1038/NATURE13180

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Apirat Chaikuad

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