Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models
about
Regulators of synaptic transmission: roles in the pathogenesis and treatment of epilepsyGenerating orally active galanin analogues with analgesic activitiesEfficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms.A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndromeNeuropeptide receptor positive allosteric modulation in epilepsy: galanin modulation revealed.GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models.Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models.Regulation of glucose and insulin release following acute and repeated treatment with the synthetic galanin analog NAX-5055Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2.Galanin receptors and ligands.Galanin regulates blood glucose level in the zebrafish: a morphological and functional study.Anticonvulsant neuropeptides as drug leads for neurological diseases.Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering.Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach.Glutamatergic Mechanisms Associated with Seizures and Epilepsy.Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.Development and pharmacologic characterization of the rat 6 Hz model of partial seizures.The novel anticonvulsant neuropeptide and galanin analogue, NAX-5055, does not alter energy and amino acid metabolism in cultured brain cells.Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics.Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2.
P2860
Q26859135-DFADB723-470F-4C75-800C-09E7E85B1A51Q28260945-D7E809C4-4D2E-416D-96A2-FA863F081797Q30560643-D2F82671-EAEB-41B1-929C-04067ED120F9Q33504524-D468AAA4-0AB6-4DFA-8D89-6196D9EA00A8Q33659932-81688EE7-AE64-4171-A033-9C7D7B41B608Q34093567-226B727B-03CE-43DB-A439-245BEF4E3CC8Q34785603-5C93D6CD-0EC2-407B-8ABA-BC4F4DB83CCBQ35478083-3661E92B-3E67-4277-9F58-7A71DC870DB1Q35753039-3359033B-A026-4ABE-85F9-AC6B10520F66Q36451712-77752044-174D-4035-9D2C-22459EAC7243Q36456375-92F812B4-F3EC-4430-B8F9-D61A021924DEQ37845684-661EC96C-CC81-48A3-A361-C3C7273403ECQ38028949-EEAA7556-0501-4EAC-9F74-08F60DE9F6EFQ38060667-1A6851C3-248E-4426-B0E7-DDAD6B42A799Q38535033-0F55CFCC-B159-4A65-955C-B4ED858E91A1Q39830106-D730D09B-898D-4B40-821A-41FD0E534A3CQ46375658-C9433A79-7AA0-446C-8500-DE18A4504596Q48041787-1C6BFE82-FEF7-4CEB-8F18-8EE70E338296Q48352136-D9C557AC-C9A4-4B06-B8D6-E81FCE7E0282Q52099813-EA3862C7-E58F-4C02-BCE8-9916EC0A0696
P2860
Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models
description
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2009
@ast
im April 2009 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: April 2009)
@en
vedecký článok (publikovaný 2009-04)
@sk
vědecký článek publikovaný v roce 2009
@cs
wetenschappelijk artikel (gepubliceerd in 2009-04)
@nl
наукова стаття, опублікована у квітні 2009
@uk
مقالة علمية (نشرت في أبريل 2009)
@ar
name
Developing novel antiepileptic ...... nin analog, in epilepsy models
@ast
Developing novel antiepileptic ...... nin analog, in epilepsy models
@en
Developing novel antiepileptic ...... nin analog, in epilepsy models
@nl
type
label
Developing novel antiepileptic ...... nin analog, in epilepsy models
@ast
Developing novel antiepileptic ...... nin analog, in epilepsy models
@en
Developing novel antiepileptic ...... nin analog, in epilepsy models
@nl
prefLabel
Developing novel antiepileptic ...... nin analog, in epilepsy models
@ast
Developing novel antiepileptic ...... nin analog, in epilepsy models
@en
Developing novel antiepileptic ...... nin analog, in epilepsy models
@nl
P2093
P2860
P1433
P1476
Developing novel antiepileptic ...... nin analog, in epilepsy models
@en
P2093
Brad R Green
Brian D Klein
Erika A Scholl
Grzegorz Bulaj
H Steve White
Liuyin Zhang
Sean P Flynn
Timothy H Pruess
P2860
P2888
P304
P356
10.1016/J.NURT.2009.01.001
P407
P577
2009-04-01T00:00:00Z
P5875
P6179
1044836650