A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
about
Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survivalFunction, regulation and pathological roles of the Gab/DOS docking proteinsSRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactomeRole and expression of FRS2 and FRS3 in prostate cancerAn alternatively spliced fibroblast growth factor (FGF)-5 mRNA is abundant in brain and translates into a partial agonist/antagonist for FGF-5 neurotrophic activityFibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein CrkCharacterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factorTransformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activationCripto: a tumor growth factor and moreThe major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signalingDistinct domains in the SHP-2 phosphatase differentially regulate epidermal growth factor receptor/NF-kappaB activation through Gab1 in glioblastoma cellsTyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its functionsoc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signalingA novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane eventsLeucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiationFGF-21 as a novel metabolic regulator.FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cellsFibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblastsPKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathwaysDocking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascadeFRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptorsA unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning proteinStimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteinsCritical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathwaysGIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathwaysBiological activity of the thyroid TRK-T3 oncogene requires signalling through ShcThe Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and diseaseA novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiationNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationEssential role of Gab1 for signaling by the c-Met receptor in vivoGenomic diversity of colorectal cancer: Changing landscape and emerging targetsFibroblast Growth Factor Signaling in Metabolic RegulationFibroblast growth factor signaling in skeletal development and diseaseFunctional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancersFibroblast growth factor signaling in the vasculatureExploring mechanisms of FGF signalling through the lens of structural biology
P2860
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P2860
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
description
1997 nî lūn-bûn
@nan
1997 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@ast
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@en
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@nl
type
label
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@ast
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@en
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@nl
prefLabel
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@ast
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@en
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@nl
P2093
P921
P3181
P1433
P1476
A lipid-anchored Grb2-binding ...... the Ras/MAPK signaling pathway
@en
P2093
D Bar-Sagi
J Schilling
J Schlessinger
T Spivak-Kroizman
Y R Hadari
P304
P3181
P356
10.1016/S0092-8674(00)80252-4
P407
P577
1997-05-30T00:00:00Z