The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines
about
Prognosis and management of acute myeloid leukemia in patients with Down syndromeMyeloid leukemia in Down syndromeTranscription factor GATA-1 and Down syndrome leukemogenesisThe GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cellsRbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiationTargeting the wee1 kinase for treatment of pediatric Down syndrome acute myeloid leukemia.Down syndrome and malignancies: a unique clinical relationship: a paper from the 2008 william beaumont hospital symposium on molecular pathologyOverexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia.Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia.High TOP2B/TOP2A expression ratio at diagnosis correlates with favourable outcome for standard chemotherapy in acute myeloid leukaemia.Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of SapacitabineIncreased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapyp53-Independent, normal stem cell sparing epigenetic differentiation therapy for myeloid and other malignanciesErythroid and megakaryocytic transformation.Malignancy in children with trisomy 21.Unique clinical and biological features of leukemia in Down syndrome children.Haematopoietic development and leukaemia in Down syndrome.Genomic profiling and directed ex vivo drug analysis of an unclassifiable myelodysplastic/myeloproliferative neoplasm progressing into acute myeloid leukemia.Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition.Cytidine deaminase genetic variants influence RNA expression and cytarabine cytotoxicity in acute myeloid leukemia.GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia.BMP meets AML: induction of BMP signaling by a novel fusion gene promotes pediatric acute leukemia.Acute leukemia in children with Down syndrome.Role of USF1 in the differential expression of the human deoxycytidine kinase gene in acute myeloid leukemia.Effect of cytosine arabinoside metabolizing enzyme expression on drug toxicity in acute myeloid leukemia.
P2860
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P2860
The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The role of cytidine deaminase ...... blasts and leukemia cell lines
@ast
The role of cytidine deaminase ...... blasts and leukemia cell lines
@en
The role of cytidine deaminase ...... blasts and leukemia cell lines
@nl
type
label
The role of cytidine deaminase ...... blasts and leukemia cell lines
@ast
The role of cytidine deaminase ...... blasts and leukemia cell lines
@en
The role of cytidine deaminase ...... blasts and leukemia cell lines
@nl
prefLabel
The role of cytidine deaminase ...... blasts and leukemia cell lines
@ast
The role of cytidine deaminase ...... blasts and leukemia cell lines
@en
The role of cytidine deaminase ...... blasts and leukemia cell lines
@nl
P2093
P1433
P1476
The role of cytidine deaminase ...... blasts and leukemia cell lines
@en
P2093
Jeffrey W Taub
Larry H Matherly
Mark L Stout
Patrick J Grohar
Robin M Flatley
Tanya L Jensen
Yaddanapudi Ravindranath
P304
P356
10.1158/0008-5472.CAN-03-2456
P407
P577
2004-01-15T00:00:00Z