The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig
about
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardiumA structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complexTargeting the sarcomere to correct muscle functionStructure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugsAdvanced heart failure: an appraisal of the potential of levosimendan in this end-stage scenario and some related ethical considerations.Levosimendan and its metabolite OR-1896 elicit KATP channel-dependent dilation in resistance arteries in vivo.Effects of the calcium sensitizer OR-1896, a metabolite of levosimendan, on post-infarct heart failure and cardiac remodelling in diabetic Goto-Kakizaki ratsLevosimendan attenuates multiple organ injury and improves survival in peritonitis-induced septic shock: studies in a rat model.The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arteriolesEffect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the ratAn emerging role for calcium sensitisation in the treatment of heart failure.The utility of levosimendan in the treatment of heart failure.Levosimendan and mortality after coronary revascularisation: a meta-analysis of randomised controlled trials.Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects.Inotropes and inodilators for acute heart failure: sarcomere active drugs in focus.Structures reveal details of small molecule binding to cardiac troponin.Screening of an FDA-approved compound library identifies levosimendan as a novel anti-HIV-1 agent that inhibits viral transcription.Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog.Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats.Levosimendan improves calcium sensitivity of diaphragm muscle fibres from a rat model of heart failureInhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart.Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary disease.Positive inotropic effect of levosimendan is correlated to its stereoselective Ca2+-sensitizing effect but not to stereoselective phosphodiesterase inhibition.The peroxynitrite evoked contractile depression can be partially reversed by antioxidants in human cardiomyocytes.Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs.The clinical effects of levosimendan are not attenuated by sulfonylureas.
P2860
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P2860
The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig
description
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im Februar 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 13 February 2004)
@en
vedecký článok (publikovaný 2004/02/13)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/02/13)
@nl
наукова стаття, опублікована в лютому 2004
@uk
مقالة علمية (نشرت في 13-2-2004)
@ar
name
The effects of levosimendan an ...... rase enzymes of the guinea pig
@ast
The effects of levosimendan an ...... rase enzymes of the guinea pig
@en
The effects of levosimendan an ...... rase enzymes of the guinea pig
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type
label
The effects of levosimendan an ...... rase enzymes of the guinea pig
@ast
The effects of levosimendan an ...... rase enzymes of the guinea pig
@en
The effects of levosimendan an ...... rase enzymes of the guinea pig
@nl
prefLabel
The effects of levosimendan an ...... rase enzymes of the guinea pig
@ast
The effects of levosimendan an ...... rase enzymes of the guinea pig
@en
The effects of levosimendan an ...... rase enzymes of the guinea pig
@nl
P2093
P1476
The effects of levosimendan an ...... rase enzymes of the guinea pig
@en
P2093
Heimo Haikala
István Edes
Jouko Levijoki
Petri Kaheinen
Szabolcs Szilágyi
Zoltán Papp
P356
10.1016/J.EJPHAR.2003.12.005
P407
P577
2004-02-13T00:00:00Z