The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS - Wikidata - wikimedia - TriplyDB

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

http://www.wikidata.org/entity/Q28244138

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SIRT2 as a Therapeutic Target for Age-Related Disorders The controversial world of sirtuins SIRT2 interacts with β-catenin to inhibit Wnt signaling output in response to radiation-induced stress The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration.Network organization of the huntingtin proteomic interactome in mammalian brain.α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.Differential expression of sirtuin family members in the developing, adult, and aged rat brain.Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis.Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7 Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein.The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet.Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model.Application of Targeted Mass Spectrometry for the Quantification of Sirtuins in the Central Nervous System.Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders Role and Therapeutic Potential of the Pro-Longevity Factor FOXO and Its Regulators in Neurodegenerative Disease.Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities.Diversification of NAD biological role: the importance of location.Neurodegeneration in Parkinson's disease: interactions of oxidative stress, tryptophan catabolites and depression with mitochondria and sirtuins.Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.Emerging Roles of Sirtuins in Ischemic Stroke.SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation.Human Sirtuin 2 Localization, Transient Interactions, and Impact on the Proteome Point to Its Role in Intracellular Trafficking.MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax and Sirt2 Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia.SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway.The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease: a meta-analysis.Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency.Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B.Sodium butyrate, a histone deacetylase Inhibitor, ameliorates SIRT2-induced memory impairment, reduction of cell proliferation, and neuroblast differentiation in the dentate gyrus.Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke.Clozapine influences cytoskeleton structure and calcium homeostasis in rat cerebral cortex and has a different proteomic profile than risperidone.Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways.Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice.

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P2860

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

http://www.wikidata.org/entity/Q28244138

description

2011 nî lūn-bûn

@nan

2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

@ast

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

@en

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

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type

label

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

@ast

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

@en

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

@nl

prefLabel

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

@ast

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

@en

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

@nl

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Human Molecular Genetics

P1476

The Sirtuin 2 microtubule deac ...... t accumulates in the aging CNS

@en

P2093

Aleksey G Kazantsev

http://www.w3.org/2001/XMLSchema#string

Allison M Amore

http://www.w3.org/2001/XMLSchema#string

Elizabeth M Tomkinson

http://www.w3.org/2001/XMLSchema#string

John W Wizeman

http://www.w3.org/2001/XMLSchema#string

Johnathan Nobles

http://www.w3.org/2001/XMLSchema#string

Luisa Quinti

http://www.w3.org/2001/XMLSchema#string

Michele M Maxwell

http://www.w3.org/2001/XMLSchema#string

Vanita Chopra

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P2860

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

HDAC6 is a microtubule-associated deacetylase

Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation

HDAC6 regulates mitochondrial transport in hippocampal neurons

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3986-96

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scholarly article

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2400041

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10.1093/HMG/DDR326

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P433

20

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P478

20

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Steven M Hersch

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2011-10-15T00:00:00Z

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51523357

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21791548

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3203628

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