Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors
about
RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiencyClass II transactivator: mastering the art of major histocompatibility complex expressionThe DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promotersAn isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DPFunctional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expressionMurine NFX.1: isolation and characterization of its messenger RNA, mapping of its chromosomal location and assessment of its developmental expressionSpecific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5NLRC5, at the Heart of Antigen PresentationMHC Class II-Deficient Combined Immunodeficiency: A Disease of Gene RegulationEndogenous retroviral long terminal repeats within the HLA-DQ locus.Deficient antigen-presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome.Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants.Molecular characterization of major histocompatibility complex class II gene expression and demonstration of antigen-specific T cell response indicate a new phenotype in class II-deficient patients.An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivatorFunctional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysisHuman chromosome 16 encodes a factor involved in induction of class II major histocompatibility antigens by interferon gamma.Promoter accessibility within the environment of the MHC is affected in class II-deficient combined immunodeficiency.Cooperativity between the J and S elements of class II major histocompatibility complex genes as enhancers in normal and class II-negative patient and mutant B cell lines.Transcription analysis of class II human leukocyte antigen genes from normal and immunodeficient B lymphocytes, using polymerase chain reactionClinical, immunological and genetic features in eleven Algerian patients with major histocompatibility complex class II expression deficiency.
P2860
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P2860
Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors
description
1989 nî lūn-bûn
@nan
1989 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Congenital immunodeficiencies ...... ations in trans-acting factors
@ast
Congenital immunodeficiencies ...... ations in trans-acting factors
@en
Congenital immunodeficiencies ...... ations in trans-acting factors
@nl
type
label
Congenital immunodeficiencies ...... ations in trans-acting factors
@ast
Congenital immunodeficiencies ...... ations in trans-acting factors
@en
Congenital immunodeficiencies ...... ations in trans-acting factors
@nl
prefLabel
Congenital immunodeficiencies ...... ations in trans-acting factors
@ast
Congenital immunodeficiencies ...... ations in trans-acting factors
@en
Congenital immunodeficiencies ...... ations in trans-acting factors
@nl
P1433
P1476
Congenital immunodeficiencies ...... ations in trans-acting factors
@en
P2093
P304
P356
10.1016/0198-8859(89)90007-4
P407
P577
1989-12-01T00:00:00Z