UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver - Wikidata - wikimedia - TriplyDB

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

http://www.wikidata.org/entity/Q28252818

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Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study Differential allelic expression of c.1568C > A at UGT2B15 is due to variation in a novel cis-regulatory element in the 3'UTR.Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system.The effect of UGT1A and UGT2B polymorphisms on colorectal cancer risk: haplotype associations and gene–environment interactions.Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15 Sex differences in UDP-glucuronosyltransferase 2B17 expression and activity Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes.Human hepatic UGT2B15 developmental expression.UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers.Uridine 5'-diphospho-glucuronosyltransferase genetic polymorphisms and response to cancer chemotherapy.UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables Impacts of the Glucuronidase Genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on Tamoxifen Metabolism in Breast Cancer Patients Uridine diphosphate-glucuronosyltransferase 2B15 D85Y gene polymorphism is associated with lower prostate cancer risk: a systematic review and meta-analysis.The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-Randomized trial comparing daily interruption of sedation and nursing-implemented sedation algorithm in medical intensive care unit patients Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction.Phytochemical regulation of UDP-glucuronosyltransferases: implications for cancer prevention.Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney.Sex differences in the expression of hepatic drug metabolizing enzymes.A pharmacokinetic/pharmacodynamic model of tumor lysis syndrome in chronic lymphocytic leukemia patients treated with flavopiridol.Comprehensive variant screening of the UGT gene family Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure.Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion.Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment.Sex differences in pharmacokinetics of antidepressants.Substrate selectivity of human intestinal UDP-glucuronosyltransferases (UGTs): in silico and in vitro insights.Gender-dependent differences in uridine 5'-diphospho-glucuronosyltransferase have implications in metabolism and clearance of xenobiotics.Hormonal regulation of hepatic drug biotransformation and transport systems.Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk.The emergence of new psychoactive substance (NPS) benzodiazepines: A review.Effect of UDP-glucuronosyltransferase 2B15 polymorphism on bisphenol A glucuronidation.Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients.The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model.Bisphenol-A glucuronidation in human liver and breast: identification of UDP-glucuronosyltransferases (UGTs) and influence of genetic polymorphisms.Functional UDP-glucuronyltransferase 2B15 polymorphism and bisphenol A concentrations in blood: results from physiologically based kinetic modelling.The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potentia Sex difference in formation of propofol metabolites: a replication study.Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers.Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia.Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects.

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P2860

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

http://www.wikidata.org/entity/Q28252818

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2004 nî lūn-bûn

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2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2004 թվականի օգոստոսին հրատարակված գիտական հոդված

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David J Greenblatt

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Lisa L von Moltke

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Tanios Bekaii-Saab

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