A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
about
The Janus kinases (Jaks)TEL is a sequence-specific transcriptional repressorhTid-1, a human DnaJ protein, modulates the interferon signaling pathwayThe human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemiaJAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatinJanus kinases in immune cell signalingDirect interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferationThe acetyltransferase 60 kDa trans-acting regulatory protein of HIV type 1-interacting protein (Tip60) interacts with the translocation E26 transforming-specific leukaemia gene (TEL) and functions as a transcriptional co-repressorRegulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathwaysTYK2 is a key regulator of the surveillance of B lymphoid tumorsTherapeutic targeting of Janus kinasesMN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in miceTwo Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activitiesNative interface of the SAM domain polymer of TEL.Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERGJAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsMolecular mechanisms of ETS transcription factor-mediated tumorigenesisTargeting JAK2 in the therapy of myeloproliferative neoplasmsIntegrating non-coding RNAs in JAK-STAT regulatory networksWrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulatorsFunctions of the Drosophila JAK-STAT pathway: Lessons from stem cellsThe JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemiaPolymerization of the SAM domain of TEL in leukemogenesis and transcriptional repressionModulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode DependentThe human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.Zebrafish as a model for leukemia and other hematopoietic disordersConstitutive activation of STAT transcription factors in acute myelogenous leukemiaJAK/STAT pathway dysregulation in tumors: a Drosophila perspectiveA unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia veraPCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocationPAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesisRandom mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitorTyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B betaCUL-4A is critical for early embryonic developmentMultifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signalingDrosophila unpaired encodes a secreted protein that activates the JAK signaling pathwayInvolvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth
P2860
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P2860
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
description
1997 nî lūn-bûn
@nan
1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@ast
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@en
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@nl
type
label
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@ast
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@en
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@nl
prefLabel
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@ast
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@en
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@nl
P2093
P1433
P1476
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
@en
P2093
J Ghysdael
M Mauchauffé
V Lacronique
P304
P356
10.1126/SCIENCE.278.5341.1309
P407
P577
1997-11-01T00:00:00Z