about
Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndromeStructural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1Double electron-electron resonance shows cytochrome P450cam undergoes a conformational change in solution upon binding substrateA Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product FormationComputational Identification of the Paralogs and Orthologs of Human Cytochrome P450 Superfamily and the Implication in Drug DiscoveryAbnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis.Gene co-expression network analysis identifies porcine genes associated with variation in metabolizing fenbendazole and flunixin meglumine in the liver.Studies of membrane topology of mitochondrial cholesterol hydroxylases CYPs 27A1 and 11A1Steady-state levels of retinal 24S-hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat.Mass spectrometry detection of isolevuglandin adduction to specific protein residues.Cytochrome P450 7A1 cholesterol 7alpha-hydroxylation: individual reaction steps in the catalytic cycle and rate-limiting ferric iron reductionThe expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells.Attenuated hypocholesterolemia following severe trauma signals risk for late ventilator-associated pneumonia, ventilator dependency, and death: a retrospective study of consecutive patientsIsolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice.Oral Rifampin treatment for longstanding chronic central serous chorioretinopathy.Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1.Transient gene delivery for functional enrichment of differentiating embryonic stem cells.Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approachesIntegrative Tissue-Specific Functional Annotations in the Human Genome Provide Novel Insights on Many Complex Traits and Improve Signal Prioritization in Genome Wide Association Studies.Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway.Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR(-/-) mice.Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1Discovering oxysterols in plasma: a window on the metabolome.Metabolomics and metabolite profiling: past heroes and future developments.The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts.Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.Female adipocyte androgen synthesis and the effects of insulinThe effect of oral lipids and circulating lipoproteins on the metabolism of drugs.From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D.Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice.Toxicological implications of modulation of gene expression by microRNAs.Cholesterol, an essential molecule: diverse roles involving cytochrome P450 enzymes.Cytochrome P450 and myocardial ischemia: potential pharmacological implication for cardioprotection.Lipid metabolism in mitochondrial membranes.Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes.Regioselective hydroxylation of steroid hormones by human cytochromes P450.Monocrotophos Induces the Expression of Xenobiotic Metabolizing Cytochrome P450s (CYP2C8 and CYP3A4) and Neurotoxicity in Human Brain Cells.MicroRNAs regulate human hepatocyte nuclear factor 4alpha, modulating the expression of metabolic enzymes and cell cycle.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Cytochrome P450s and cholesterol homeostasis
@ast
Cytochrome P450s and cholesterol homeostasis
@en
Cytochrome P450s and cholesterol homeostasis
@nl
type
label
Cytochrome P450s and cholesterol homeostasis
@ast
Cytochrome P450s and cholesterol homeostasis
@en
Cytochrome P450s and cholesterol homeostasis
@nl
prefLabel
Cytochrome P450s and cholesterol homeostasis
@ast
Cytochrome P450s and cholesterol homeostasis
@en
Cytochrome P450s and cholesterol homeostasis
@nl
P3181
P1476
Cytochrome P450s and cholesterol homeostasis
@en
P2093
Irina A Pikuleva
P304
P3181
P356
10.1016/J.PHARMTHERA.2006.05.014
P407
P577
2006-12-01T00:00:00Z