Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy
about
sameAs
RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disordersStructural studies of CNG repeatsMechanisms of RNA-induced toxicity in CAG repeat disordersRegulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in CancerTriplet repeat-derived siRNAs enhance RNA-mediated toxicity in a Drosophila model for myotonic dystrophyAtomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseasesCrystal structures of CGG RNA repeats with implications for fragile X-associated tremor ataxia syndromeCrystallographic characterization of CCG repeatsDrosophila as an In Vivo Model for Human Neurodegenerative DiseaseRNA toxicity is a component of ataxin-3 degeneration in DrosophilaGenetic and chemical modifiers of a CUG toxicity model in DrosophilaBiological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models.New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeatsReversible model of RNA toxicity and cardiac conduction defects in myotonic dystrophy.Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.Mechanistic determinants of MBNL activityRepression of nuclear CELF activity can rescue CELF-regulated alternative splicing defects in skeletal muscle models of myotonic dystrophyRepeat length and RNA expression level are not primary determinants in CUG expansion toxicity in Drosophila modelsRNA gain-of-function in spinocerebellar ataxia type 8.Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophyMBNL1 binds GC motifs embedded in pyrimidines to regulate alternative splicing.Long tract of untranslated CAG repeats is deleterious in transgenic miceMyotonic dystrophies 1 and 2: complex diseases with complex mechanisms.Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcriptsDesign of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching.Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive.Diced triplets expose neurons to RISC.MBNL proteins and their target RNAs, interaction and splicing regulation.Dystrophia myotonia: why focus on foci?Mutant (CCTG)n expansion causes abnormal expression of zinc finger protein 9 (ZNF9) in myotonic dystrophy type 2.The role of CELF proteins in neurological disorders.Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy.Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1.Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs.Practical Aspects of microRNA Target Prediction.RNA Foci, CUGBP1, and ZNF9 are the primary targets of the mutant CUG and CCUG repeats expanded in myotonic dystrophies type 1 and type 2Triplet repeat RNA structure and its role as pathogenic agent and therapeutic targetAntagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins.RNA-binding protein misregulation in microsatellite expansion disordersTherapeutic impact of systemic AAV-mediated RNA interference in a mouse model of myotonic dystrophy.
P2860
Q26823908-5D480963-B52F-44A0-B15A-730C7002C76BQ26851232-D93ACA44-8FD2-4C03-8D3E-15710ED0B96BQ26860030-EAB58B0A-757E-42F1-845E-CBE1B45CF3B2Q27001635-4EFC1417-6B1B-4F3D-9C2F-40539408B1C8Q27342852-10FA4B76-38F0-4720-9771-02FFBC3BB5FBQ27664034-90F131FF-6FCA-4C63-A750-3CFE94AC72C9Q27667903-27B2A814-2C79-46B4-AD1B-33FC1ECDACACQ27681279-45DA5712-0AD6-4E6A-A701-BC4725A194E4Q28088777-71ACE039-4D39-4B13-ABA2-FD968640576DQ28278448-4E75B635-18A2-4978-A98A-83C57AAE9E89Q28472129-E81D2ED1-71A9-4DEF-9873-E0987A1ECC7CQ30377390-DD36D7D4-F65A-4673-BB8D-A623E6AFC075Q30427374-814B885B-3DA0-4025-87D6-86D4F881A3A5Q30435398-FCC7D7D6-1556-4E0F-97FA-6335763C5DCEQ30586121-58167DC3-5607-44DA-8D74-E333AC5A4052Q30830825-0902AEDE-BEE6-4FD6-A2CD-22BFE615ADB3Q31053307-E49DDC68-85D9-4FAE-AC6C-859D6F54CA9DQ33316025-F9802BCC-0D89-42E9-A5B5-1FB341F9978BQ33493406-9518372C-04E0-43C2-B2A2-12B072E2E569Q33569231-7AA41D16-E200-46AA-9C26-5DA17A9579AFQ33783196-1822D87E-5E8E-4153-B388-D77C2F3FAE3FQ33808904-30DBA8BB-0436-490C-932A-AAD882B62B0AQ33867667-2582663D-C443-43CF-A91C-D1DA857F9497Q34129996-17EEB584-93A0-4616-AB9D-065F6C57D667Q34149072-1F15D773-0B14-4031-A76D-55B5E242745BQ34158462-8668DACE-E476-4F8E-A1C8-A5944D1F025BQ34181404-A83A2135-5F2D-4C1F-B0C3-F705EE9BB338Q34248811-9AB461CB-3163-4252-A051-C41E636903D6Q34326165-7619F996-187A-4487-802F-53B5294AA058Q34358301-AE44BB5F-D945-4128-B2BD-61973756FCC7Q34706897-55BEB5C2-BDB9-4D55-AB23-CDEEEA5739B8Q34984541-1B15934E-91F0-45D8-B019-CA6800D2EAC5Q35031314-89037BFF-5ED3-4987-9264-F84AF5F68950Q35056048-7E0753C9-8335-4332-81E6-05EE3DC29F48Q35237559-F7FF4090-AFE8-43D8-BF4B-FD4F809F136AQ35474587-EDB025C6-C8CF-46D6-B864-05CFC384D441Q35633648-16AE8071-EC46-40D2-939A-63344E6B7512Q35664126-F8644CA5-9DA1-45AE-922B-4D66E592A6F3Q35789502-BF6C9552-9A9F-433A-812E-753B1C75FFC2Q35924075-89685311-A476-489F-A142-BFEC955834A3
P2860
Colocalization of muscleblind with RNA foci is separable from mis-regulation of alternative splicing in myotonic dystrophy
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@ast
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@en
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@nl
type
label
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@ast
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@en
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@nl
prefLabel
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@ast
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@en
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@nl
P2093
P3181
P356
P1476
Colocalization of muscleblind ...... splicing in myotonic dystrophy
@en
P2093
Michael A Mancini
Michael G Poulos
Rajesh S Savkur
Thomas A Cooper
P304
P3181
P356
10.1242/JCS.02404
P407
P577
2005-06-16T00:00:00Z