Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin
about
Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depressionThe KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriersKlotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in miceKlotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms.Molecular basis of Klotho: from gene to function in agingPromoter methylation and age-related downregulation of Klotho in rhesus monkeyIdentification of novel small molecules that elevate Klotho expression.The role of Klotho in energy metabolism.Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease.Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk.Klotho acts as a tumor suppressor in cancers.Noncardiovascular mortality in CKD: an epidemiological perspective.Klotho: a novel biomarker for cancer.The aging suppressor klotho: a potential regulator of growth hormone secretion.Klotho expression in cervical cancer: differential expression in adenocarcinoma and squamous cell carcinoma.Changes in expression of klotho affect physiological processes, diseases, and cancer.
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P2860
Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
@ast
Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
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Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
@nl
type
label
Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
@ast
Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
@en
Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
@nl
prefLabel
Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
@ast
Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
@en
Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
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P2860
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Functional variant of KLOTHO: ...... n carriers of Ashkenazi origin
@en
P2093
B Y Karlan
E Friedman
H P Koeffler
L Abramovitz
L S Freedman
P2860
P2888
P3181
P356
10.1038/ONC.2009.301
P407
P577
2010-01-07T00:00:00Z
P5875
P6179
1016163236