Target identification in chemical genetics: the (often) missing link
about
An unbiased cell morphology-based screen for new, biologically active small moleculesNext-generation antimicrobials: from chemical biology to first-in-class drugsTarget prediction utilising negative bioactivity data covering large chemical spaceComparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitorSimultaneous structure-activity studies and arming of natural products by C-H amination reveal cellular targets of eupalmerin acetate.Considerations for designing chemical screening strategies in plant biology.Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling.Triazine-based tyrosinase inhibitors identified by chemical genetic screening.Diversity-oriented synthesis: exploring the intersections between chemistry and biology.Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads.Probing cell-division phenotype space and Polo-like kinase function using small molecules.Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal modelsNatural products as chemical probesKRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoterEnergetics-based discovery of protein-ligand interactions on a proteomic scale.The end game of chemical genetics: target identification.Targeting the cancer kinome through polypharmacology.Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells.Small-molecule modulators of Listeria monocytogenes biofilm developmentThe yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells: potential and limitationsSimplified proteomics approach to discover protein-ligand interactions.Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.Fully functionalized small-molecule probes for integrated phenotypic screening and target identification.Chemical biology applied to the study of bacterial pathogens.Target identification and mechanism of action in chemical biology and drug discovery.Discovery of a Potent Anti-tumor Agent through Regioselective Mono-N-acylation of 7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine.Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ.Cancer stem cells as a target population for drug discovery.The chemistry and pharmacology of privileged pyrroloquinazolines.Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinibIntegration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.Competitive Growth Enhances Conditional Growth Mutant Sensitivity to Antibiotics and Exposes a Two-Component System as an Emerging Antibacterial Target in Burkholderia cenocepaciaForward in reverse: how reverse genetics complements chemical genetics.Screening and synthesis: high throughput technologies applied to parasitology.Charting protein complexes, signaling pathways, and networks in the immune system.Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane.The Synthetic Elicitor DPMP (2,4-dichloro-6-{(E)-[(3-methoxyphenyl)imino]methyl}phenol) Triggers Strong Immunity in Arabidopsis thaliana and Tomato.Chemoselective hydroxyl group transformation: an elusive target.High-content screening for the discovery of pharmacological compounds: advantages, challenges and potential benefits of recent technological developments.
P2860
Q24806083-1CDFF68C-9CCE-4441-9DAD-4DFB64655633Q26799749-48A7CFD6-5679-4467-8137-E0FCA75380E6Q27902317-4CA8DBBA-40E7-4A5E-9026-F83438DC4E9AQ28830547-49825061-3CDE-48C6-B470-199C57B78BF6Q30579599-85F2DF77-6BBC-4AC4-ADC2-560C55C951ACQ30636976-C28D55A1-8539-4A34-A3CF-B5D39DC2EC2BQ33224424-7E0AF113-CB2B-466D-8E4F-7D6134B12786Q33226924-6B18028D-B49E-4650-80F1-09207A82AC82Q33231454-DCE43D3A-293B-4412-A240-F046BC282A6BQ33252424-DE7B2F74-FB39-4CF4-8978-C447A802897BQ33259741-5EBBC172-5398-4CA3-9831-05BA1C5D1CD0Q33481617-BBABFD15-46F6-45B8-8E20-B94ABA5616D3Q33590047-FCF8B220-A6F9-4FC6-92E5-BA9A4947B463Q33747276-F75500D2-51C2-469D-94E9-5C2926BAA3DCQ33825852-82B41B1B-9FC3-4BE4-B6DF-E098A6C8D8B7Q33852378-BCAD16D7-F1D2-415F-BEFC-4C70578773A0Q33893019-83EBD6C6-7844-4A0A-A5D4-12A84AE1FD2AQ33998839-5EDEED5D-D7A8-4AB5-AC99-9610586AB856Q34109642-09F526C2-5A1B-4259-9D3B-AAD246BCBB35Q34284036-0890BF0D-6827-4EE9-BE78-43081293C233Q34284128-F02D64CF-4C5D-4E4A-9C4A-B96BC576F6CAQ34290756-26D2D7C8-1396-45E9-9538-D8623B637263Q34293367-BCDD338F-5E13-4DF6-A7CC-0D64877AFFC0Q34448285-C25C1096-ECA6-4EBB-912C-C587349CF5BDQ34626974-F1EECD04-E4D7-4243-AC8C-D9161C0362FFQ35027063-9FC4FDF1-0343-4970-81D7-D26CA53CA6F8Q35142055-E5889BED-3984-437F-A732-F7F07F88D969Q35390334-0407AD2E-36F5-4404-A257-D500B6A64B06Q35546796-55E36092-67A0-4F17-9E7C-E5F54A51F008Q35676957-D02A247C-1930-41BF-8D93-5B3E3DE78C35Q35925610-4F903AFF-8EEB-4CCD-A323-35638213C713Q35954703-A458BA67-BDBB-4700-A3DC-ACDFE9200938Q36178767-F899E3A1-767E-41CD-95B7-95E5EE247587Q36186965-1A898FB6-C9E6-461A-ACB4-258070580BD9Q36385090-BF5BEA0B-AAE6-4812-9B5E-8030D061D43FQ36453373-2C958D77-20DB-4FA9-8EA8-7C2C5794FA7CQ36857331-8D2146B7-86F8-4396-8A19-75C8CA96A021Q37093241-6DF11B0D-4715-4194-8F28-CE0A6D569063Q38018503-D096A4DA-E974-4FFB-84C4-1A84A4036812Q38028519-00D43511-466F-488D-BEF3-283CA8E273FC
P2860
Target identification in chemical genetics: the (often) missing link
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
Target identification in chemical genetics: the (often) missing link
@ast
Target identification in chemical genetics: the (often) missing link
@en
Target identification in chemical genetics: the (often) missing link
@nl
type
label
Target identification in chemical genetics: the (often) missing link
@ast
Target identification in chemical genetics: the (often) missing link
@en
Target identification in chemical genetics: the (often) missing link
@nl
prefLabel
Target identification in chemical genetics: the (often) missing link
@ast
Target identification in chemical genetics: the (often) missing link
@en
Target identification in chemical genetics: the (often) missing link
@nl
P3181
P1476
Target identification in chemical genetics: the (often) missing link
@en
P2093
Lyle Burdine
Thomas Kodadek
P3181
P356
10.1016/J.CHEMBIOL.2004.05.001
10.1016/S1074-5521(04)00123-1
P407
P577
2004-05-01T00:00:00Z