Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia
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The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 proteinThe p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/MThe AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLFSite-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia.Classification of human B-ZIP proteins based on dimerization propertiesPbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemiaPivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytesThe rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferencesDNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLFDNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion proteinAnalysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targetingVBP and RelA regulate avian leukosis virus long terminal repeat-enhanced transcription in B cellsTranscription factor-mediated reprogramming toward hematopoietic stem cellsCloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemiaGATA factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cellsActivation of the smooth muscle-specific telokin gene by thyrotroph embryonic factor (TEF).Identification of multiple transcription factors, HLF, FTF, and E4BP4, controlling hepatitis B virus enhancer II.B-ZIP proteins encoded by the Drosophila genome: evaluation of potential dimerization partnersThe C/EBP family of transcription factors in the liver and other organs.Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic miceA novel pathway of TEF regulation mediated by microRNA-125b contributes to the control of actin distribution and cell shape in fibroblasts.D-site binding protein transactivation requires the proline- and acid-rich domain and involves the coactivator p300.The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior.Involvement of thyrotroph embryonic factor in calcium-mediated regulation of gene expression.Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes.Role for homodimerization in growth deregulation by E2a fusion proteins.CREB is one component of the binding complex of the Ces-2/E2A-HLF binding element and is an integral part of the interleukin-3 survival signal.The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors.E2A-HLF usurps control of evolutionarily conserved survival pathways.E4BP4/NFIL3, a PAR-related bZIP factor with many roles.CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP.Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia.In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia.The two PAR leucine zipper proteins, TEF and DBP, display similar circadian and tissue-specific expression, but have different target promoter preferences.Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice.Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinomaGenomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature
P2860
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P2860
Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia
description
1992 nî lūn-bûn
@nan
1992 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
name
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@ast
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@en
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@nl
type
label
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@ast
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@en
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@nl
prefLabel
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@ast
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@en
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@nl
P2093
P3181
P356
P1433
P1476
Hlf, a novel hepatic bZIP prot ...... ) acute lymphoblastic leukemia
@en
P2093
K Ohyashiki
M L Cleary
S P Hunger
P304
P3181
P356
10.1101/GAD.6.9.1608
P407
P577
1992-09-01T00:00:00Z