The transferable tail: fusion of the N-terminal acidic extension of heparin cofactor II to alpha1-proteinase inhibitor M358R specifically increases the rate of thrombin inhibition
about
Retention of thrombin inhibitory activity by recombinant serpins expressed as integral membrane proteins tethered to the surface of mammalian cells.The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand.Fusion of the C-terminal triskaidecapeptide of hirudin variant 3 to alpha1-proteinase inhibitor M358R increases the serpin-mediated rate of thrombin inhibition.Phage display of the serpin alpha-1 proteinase inhibitor randomized at consecutive residues in the reactive centre loop and biopanned with or without thrombin.
P2860
The transferable tail: fusion of the N-terminal acidic extension of heparin cofactor II to alpha1-proteinase inhibitor M358R specifically increases the rate of thrombin inhibition
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
The transferable tail: fusion ...... he rate of thrombin inhibition
@ast
The transferable tail: fusion ...... he rate of thrombin inhibition
@en
The transferable tail: fusion ...... he rate of thrombin inhibition
@nl
type
label
The transferable tail: fusion ...... he rate of thrombin inhibition
@ast
The transferable tail: fusion ...... he rate of thrombin inhibition
@en
The transferable tail: fusion ...... he rate of thrombin inhibition
@nl
prefLabel
The transferable tail: fusion ...... he rate of thrombin inhibition
@ast
The transferable tail: fusion ...... he rate of thrombin inhibition
@en
The transferable tail: fusion ...... he rate of thrombin inhibition
@nl
P2093
P356
P1433
P1476
The transferable tail: fusion ...... he rate of thrombin inhibition
@en
P2093
Jason S Sutherland
Marc L Filion
Varsha Bhakta
P304
11444-11452
P356
10.1021/BI0609624
P407
P577
2006-09-01T00:00:00Z