Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2
about
Solution structure of the A4 domain of factor XI sheds light on the mechanism of zymogen activationPlatelets and Alzheimer's disease: Potential of APP as a biomarkerAlzheimer's disease--a panorama glimpseDeterminants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with MesotrypsinThe P 2 ′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activityPresence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitorsSequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.Selection and characterization of a DNA aptamer inhibiting coagulation factor XIa.Functional role of residue 193 (chymotrypsin numbering) in serine proteases: influence of side chain length and beta-branching on the catalytic activity of blood coagulation factor XIa.Structure and function of factor XIAnalysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIaMechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitorEngineering kunitz domain 1 (KD1) of human tissue factor pathway inhibitor-2 to selectively inhibit fibrinolysis: properties of KD1-L17R variantThe role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2Evolution, expansion and expression of the Kunitz/BPTI gene family associated with long-term blood feeding in Ixodes ScapularisProductive recognition of factor IX by factor XIa exosites requires disulfide linkage between heavy and light chains of factor XIa.The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis.P1 and P2' site mutations convert protease nexin-2 from a factor XIa inhibitor to a plasmin inhibitorA catalytic domain exosite (Cys527-Cys542) in factor XIa mediates binding to a site on activated platelets.Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo.Molecular characterization of FXI deficiency.The many faces of the contact pathway and their role in thrombosis.Crystal structure of the factor XI zymogen reveals a pathway for transactivation.Fasxiator, a novel factor XIa inhibitor from snake venom, and its site-specific mutagenesis to improve potency and selectivity.Prochemerin cleavage by factor XIa links coagulation and inflammation.Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases.Factor XI deficiencyMechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1
P2860
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P2860
Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
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2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structural and mutational anal ...... tor domain of protease nexin 2
@ast
Structural and mutational anal ...... tor domain of protease nexin 2
@en
Structural and mutational anal ...... tor domain of protease nexin 2
@nl
type
label
Structural and mutational anal ...... tor domain of protease nexin 2
@ast
Structural and mutational anal ...... tor domain of protease nexin 2
@en
Structural and mutational anal ...... tor domain of protease nexin 2
@nl
prefLabel
Structural and mutational anal ...... tor domain of protease nexin 2
@ast
Structural and mutational anal ...... tor domain of protease nexin 2
@en
Structural and mutational anal ...... tor domain of protease nexin 2
@nl
P2093
P2860
P356
P1476
Structural and mutational anal ...... tor domain of protease nexin 2
@en
P2093
Duraiswamy Navaneetham
James E Strickler
Peter N Walsh
Pramod Pandey
Robert E Babine
Sherin S Abdel-Meguid
P2860
P304
P356
10.1074/JBC.M504990200
P407
P577
2005-10-28T00:00:00Z