The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity
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Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasmCharacterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphataseStabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescenceReciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulationPTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions.Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradationMitogen-activated Protein Kinase (MAPK) Phosphatase 3-mediated Cross-talk between MAPKs ERK2 and p38Reciprocal regulation between Slt2 MAPK and isoforms of Msg5 dual-specificity protein phosphatase modulates the yeast cell integrity pathway.A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase.YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae.Differential regulation of the cell wall integrity mitogen-activated protein kinase pathway in budding yeast by the protein tyrosine phosphatases Ptp2 and Ptp3.Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathwayMolecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domainc-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1Two kinds of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-3, are differentially activated by acute and chronic methamphetamine treatment in the rat brainActivation of p42 mitogen-activated protein kinase (MAPK), but not c-Jun NH(2)-terminal kinase, induces phosphorylation and stabilization of MAPK phosphatase XCL100 in Xenopus oocytesMAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alphaA novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines.Intracellular expression profiling by laser capture microdissection: three novel components of the neuromuscular junction.Multiple regions of MAP kinase phosphatase 3 are involved in its recognition and activation by ERK2.A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells.Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell linesThe role of protein phosphatases in the regulation of mitogen and stress-activated protein kinases.Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells.MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic developmentThe C.elegans MAPK phosphatase LIP-1 is required for the G(2)/M meiotic arrest of developing oocytes.Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity.Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446.Systematic review of genome-wide gene expression studies of bipolar disorderSignalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions.Dual Specificity Phosphatase 5, a Specific Negative Regulator of ERK Signaling, Is Induced by Serum Response Factor and Elk-1 Transcription Factor
P2860
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P2860
The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
The mitogen-activated protein ...... ding and enzymatic specificity
@ast
The mitogen-activated protein ...... ding and enzymatic specificity
@en
The mitogen-activated protein ...... ding and enzymatic specificity
@nl
type
label
The mitogen-activated protein ...... ding and enzymatic specificity
@ast
The mitogen-activated protein ...... ding and enzymatic specificity
@en
The mitogen-activated protein ...... ding and enzymatic specificity
@nl
prefLabel
The mitogen-activated protein ...... ding and enzymatic specificity
@ast
The mitogen-activated protein ...... ding and enzymatic specificity
@en
The mitogen-activated protein ...... ding and enzymatic specificity
@nl
P2093
P356
P1476
The mitogen-activated protein ...... ding and enzymatic specificity
@en
P2093
A Theodosiou
C Gillieron
N Rodrigues
S Arkinstall
U Boschert
P304
P356
10.1074/JBC.273.15.9323
P407
P577
1998-04-10T00:00:00Z