The LKB1 tumor suppressor negatively regulates mTOR signaling
about
Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumorsTargeting tumorigenesis: development and use of mTOR inhibitors in cancer therapyA new role of NUAK1: directly phosphorylating p53 and regulating cell proliferationTBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1Agonist antibodies activating the Met receptor protect cardiomyoblasts from cobalt chloride-induced apoptosis and autophagyAdiponectin lowers glucose production by increasing SOGASecond AKT: the rise of SGK in cancer signallingFolliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signalingSIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasisAMPK phosphorylation of raptor mediates a metabolic checkpointSignaling by target of rapamycin proteins in cell growth controlRegulation of mTOR and cell growth in response to energy stress by REDD1.Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationRegulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexMicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cellsMolecular biology of lung cancerMolecular biology of lung cancer: clinical implicationsIntegrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumorsThe mTOR signalling pathway in human cancerThe tuberous sclerosis complexNext-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategyAn emerging role for TOR signaling in mammalian tissue and stem cell physiologymTOR: from growth signal integration to cancer, diabetes and ageingThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthTargeting the mTOR signaling network for cancer therapyTurnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosisBalancing Akt with S6K: implications for both metabolic diseases and tumorigenesisAutophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast CancerPI3K/Akt/mTOR inhibitors in breast cancerEffect of Dietary ω-3 Polyunsaturated Fatty Acid DHA on Glycolytic Enzymes and Warburg Phenotypes in CancerTargeting LKB1 in cancer - exposing and exploiting vulnerabilitiesMechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cellsNovel targeting of phosphatidylinositol 3-kinase and mammalian target of rapamycin in renal cell carcinomaModulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectivesAutophagy in malignant transformation and cancer progressionUse of mTOR inhibitors in the treatment of breast cancer: an evaluation of factors that influence patient outcomesThe role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologiesReinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease modelTSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.
P2860
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P2860
The LKB1 tumor suppressor negatively regulates mTOR signaling
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The LKB1 tumor suppressor negatively regulates mTOR signaling
@ast
The LKB1 tumor suppressor negatively regulates mTOR signaling
@en
The LKB1 tumor suppressor negatively regulates mTOR signaling
@nl
type
label
The LKB1 tumor suppressor negatively regulates mTOR signaling
@ast
The LKB1 tumor suppressor negatively regulates mTOR signaling
@en
The LKB1 tumor suppressor negatively regulates mTOR signaling
@nl
prefLabel
The LKB1 tumor suppressor negatively regulates mTOR signaling
@ast
The LKB1 tumor suppressor negatively regulates mTOR signaling
@en
The LKB1 tumor suppressor negatively regulates mTOR signaling
@nl
P2093
P3181
P1433
P1476
The LKB1 tumor suppressor negatively regulates mTOR signaling
@en
P2093
Brendan D Manning
Lyle Lopez
Monica Kosmatka
Reuben J Shaw
Ronald A DePinho
P3181
P356
10.1016/J.CCR.2004.06.007
P407
P577
2004-07-01T00:00:00Z