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The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skinMolecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a modelBlocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndromeModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesWhen lamins go bad: nuclear structure and diseaseChemical inhibition of CaaX protease activity disrupts yeast Ras localization.Analysis of prelamin A biogenesis reveals the nucleus to be a CaaX processing compartmentEmbryonic senescence and laminopathies in a progeroid zebrafish modelExpansion of the nucleoplasmic reticulum requires the coordinated activity of lamins and CTP:phosphocholine cytidylyltransferase alpha.Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A.Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndromeAbsence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegansThematic review series: Adipocyte Biology. Lipodystrophies: windows on adipose biology and metabolism.Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.Mice that express farnesylated versions of prelamin A in neurons develop achalasia.Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type laminsSevere hepatocellular disease in mice lacking one or both CaaX prenyltransferases.Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis.Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA.Hallermann-Streiff Syndrome: No Evidence for a Link to Laminopathies.HIV protease inhibitors and nuclear lamin processing: getting the right bells and whistles.Understanding the roles of nuclear A- and B-type lamins in brain development.Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A.Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter.Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene MutationsPrelamin A processing, accumulation and distribution in normal cells and laminopathy disorders.Investigation of splicing changes and post-translational processing of LMNA in sporadic inclusion body myositis.Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skinHeterologous expression studies of Saccharomyces cerevisiae reveal two distinct trypanosomatid CaaX protease activities and identify their potential targets.ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders.Lamin A/C Cardiomyopathies: Current Understanding and Novel Treatment Strategies.Alkynyl-farnesol reporters for detection of protein S-prenylation in cells.Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors.Progerin impairs chromosome maintenance by depleting CENP-F from metaphase kinetochores in Hutchinson-Gilford progeria fibroblasts.The tail domain of lamin B1 is more strongly modulated by divalent cations than lamin A.Development of detection method for novel fusion gene using GeneChip exon array.Structure and stability of the lamin A tail domain and HGPS mutant.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Prelamin A farnesylation and progeroid syndromes
@ast
Prelamin A farnesylation and progeroid syndromes
@en
Prelamin A farnesylation and progeroid syndromes
@nl
type
label
Prelamin A farnesylation and progeroid syndromes
@ast
Prelamin A farnesylation and progeroid syndromes
@en
Prelamin A farnesylation and progeroid syndromes
@nl
prefLabel
Prelamin A farnesylation and progeroid syndromes
@ast
Prelamin A farnesylation and progeroid syndromes
@en
Prelamin A farnesylation and progeroid syndromes
@nl
P2093
P2860
P3181
P356
P1476
Prelamin A farnesylation and progeroid syndromes
@en
P2093
Loren G Fong
Margarita Meta
Shao H Yang
P2860
P304
39741-39745
P3181
P356
10.1074/JBC.R600033200
P407
P577
2006-11-07T00:00:00Z