about
Enzymatic transition states, transition-state analogs, dynamics, thermodynamics, and lifetimesThe catalytic consequences of experimental evolution. Transition-state structure during catalysis by the evolved beta-galactosidases of Escherichia coli (ebg enzymes) changed by a single mutational eventEffects of deuterium substitution alpha and beta to the reaction centre, 18O substitution in the leaving group, and aglycone acidity on hydrolyses of aryl glucosides and glucosyl pyridinium ions by yeast alpha-glucosidase. A probable failure of theImino-oxy acetic acid dealkylation as evidence for an inner-sphere alcohol intermediate in the reaction catalyzed by peptidylglycine alpha-hydroxylating monooxygenase.The use of isotope effects to determine enzyme mechanisms.Natural intramolecular isotope measurements in physiology: elements of the case for an effort toward high-precision position-specific isotope analysis.Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.A 70-amino acid zinc-binding polypeptide fragment from the regulatory chain of aspartate transcarbamoylase causes marked changes in the kinetic mechanism of the catalytic trimer.A method to determine 18 O kinetic isotope effects in the hydrolysis of nucleotide triphosphates.Probing enzyme phosphoester interactions by combining mutagenesis and chemical modification of phosphate ester oxygens.EPR-kinetic isotope effect study of the mechanism of radical-mediated dehydrogenation of an alcohol by the radical SAM enzyme DesII.Kinetic and spectroscopic analysis of the catalytic role of H79 in the methionine aminopeptidase from Escherichia coli.Experimental analyses of the chemical dynamics of ribozyme catalysisEntropic origin of cobalt-carbon bond cleavage catalysis in adenosylcobalamin-dependent ethanolamine ammonia-lyase.Transition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects.The power of integrating kinetic isotope effects into the formalism of the Michaelis-Menten equation.Determination of relative rate constants for in vitro RNA processing reactions by internal competition.Uridine phosphorylase from Trypanosoma cruzi: kinetic and chemical mechanisms.Isotope effect studies on the cytochrome P450 enzymes.Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis.Model for magnetic field effects on radical pair recombination in enzyme kineticsKinetic isotope effects for RNA cleavage by 2'-O- transphosphorylation: nucleophilic activation by specific base.Adenosylcobalamin-dependent methylmalonyl-CoA mutase from Propionibacterium shermanii. Active holoenzyme produced from Escherichia coli.Synthesis of Mono- and Di-Deuterated (2S, 3S)-3-Methylaspartic Acids to Facilitate Measurement of Intrinsic Kinetic Isotope Effects in Enzymes.Investigation of alpha-deuterium kinetic isotope effects on the purine nucleoside phosphorylase reaction by the equilibrium-perturbation technique.Methylmalonyl-CoA mutase from Propionibacterium shermanii. Evidence for the presence of two masked cysteine residues.Natural abundance carbon isotope composition of isoprene reflects incomplete coupling between isoprene synthesis and photosynthetic carbon flow.Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps.Stable carbon isotope discrimination by human 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Theory and Application of the Relationship Between Steady-State Isotope Effects on Enzyme Intermediate Concentrations and Net Rate Constants.Molecular and enzymatic characterizations of novel bifunctional 3beta-hydroxysteroid dehydrogenases/C-4 decarboxylases from Arabidopsis thaliana.Investigation of the mechanism of the SpnF-catalyzed [4+2]-cycloaddition reaction in the biosynthesis of spinosyn A.Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus.
P2860
Q28240827-9F959737-A2AA-4D3A-BE74-C635407937C9Q28341139-03711388-E97F-4308-A641-D05C9CF00ED0Q28362279-B957FB92-7649-4D81-948C-DF4F839B6F7BQ30490664-941035BE-C29B-4D48-B64B-886E9D1672EDQ34272885-2CAE4C18-50BE-46A6-8C53-253466FA6F1DQ34315624-981711A6-B88F-4276-AECC-782B9DB3A602Q36219705-BB7D9D25-71DB-4B6E-A70C-82DE4C1BBCCDQ36278747-9AC66EC6-F61A-4D68-A613-A550EDBA31B4Q36464567-2807C05D-A063-4A1C-A691-4E9C78C3A15BQ36559673-67FACDE6-B83A-47E3-ACAB-024BEAB6CF9BQ36598366-4DF505A5-439E-4539-87C6-CA461A003BDEQ37289154-D3847F75-061A-4991-8AFB-3B066756A7C5Q37308629-9C70EA8E-3CA5-47D6-899E-29E278DD1BABQ37340338-84888873-6586-4E51-A114-54AF3B7E0166Q37389991-495E7951-4E7C-4D1A-B1E1-CF2576BB1BFBQ37734232-561B52F3-8573-4673-AABE-E34DD53233DCQ38244840-2B133241-1B2E-48A6-BF13-2B8D01A60F01Q38942581-55CBA675-435A-4282-A291-EDBDFBB216A4Q40463563-B930E1E2-9B85-45E5-8D1A-85A6C3E7FA81Q40915435-FF9BCD43-B636-4583-86CC-02F32D762572Q41916720-67C7B89F-710D-460D-B6FF-0130F5A5C77AQ41959334-E39456EE-B67B-4B8D-AA95-2145B93CF041Q42007721-7F154A5A-805F-49DA-B2AF-F89C39ADC74BQ42749630-3D64FD9A-8F30-4573-AB3A-999D8DECB12AQ42821145-DC6CC64C-AE19-4AB9-B2BB-726056E41834Q42836291-87C1DFF6-001D-4CC8-9916-46C5988B5642Q44401320-2ADABE9C-C68B-4487-BBCD-6FDDF22F64F7Q46384136-B8229CDC-D0CF-4884-B46F-46FAF91D2E30Q46453525-4BDEE138-7DA2-43A3-AA84-DF42A05B299BQ47686999-2309C950-3A29-4171-B6B3-D1C577712112Q48086127-879EF399-34A6-4F16-AC7E-1725F161235FQ48125701-604E2320-4964-446A-A20D-FC29B75CE59CQ50962681-86F6EE57-E4D0-45AB-A0C4-6CAB6A8748BE
P2860
description
1982 nî lūn-bûn
@nan
1982 թուականին հրատարակուած գիտական յօդուած
@hyw
1982 թվականին հրատարակված գիտական հոդված
@hy
1982年の論文
@ja
1982年学术文章
@wuu
1982年学术文章
@zh-cn
1982年学术文章
@zh-hans
1982年学术文章
@zh-my
1982年学术文章
@zh-sg
1982年學術文章
@yue
name
Use of isotope effects to elucidate enzyme mechanisms
@ast
Use of isotope effects to elucidate enzyme mechanisms
@en
Use of isotope effects to elucidate enzyme mechanisms
@nl
type
label
Use of isotope effects to elucidate enzyme mechanisms
@ast
Use of isotope effects to elucidate enzyme mechanisms
@en
Use of isotope effects to elucidate enzyme mechanisms
@nl
prefLabel
Use of isotope effects to elucidate enzyme mechanisms
@ast
Use of isotope effects to elucidate enzyme mechanisms
@en
Use of isotope effects to elucidate enzyme mechanisms
@nl
P2860
P1476
Use of isotope effects to elucidate enzyme mechanisms
@en
P2093
W W Cleland
P2860
P304
P356
10.3109/10409238209108715
P407
P577
1982-01-01T00:00:00Z