Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model
about
Pluronic based β-cyclodextrin polyrotaxanes for treatment of Niemann-Pick Type C disease.Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease.Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage.Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.Niemann-Pick type C: focus on the adolescent/adult onset form.Lysosome and endoplasmic reticulum quality control pathways in Niemann-Pick type C disease.Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells.Systemic AAV9 gene therapy improves the lifespan of mice with Niemann-Pick disease, type C1.PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder.Lysosomal pH-inducible supramolecular dissociation of polyrotaxanes possessing acid-labile N-triphenylmethyl end groups and their therapeutic potential for Niemann-Pick type C diseaseFTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease.Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease.Involvement of IL-17 in Secondary Brain Injury After a Traumatic Brain Injury in Rats.Translational gap in ongoing clinical trials for glioma.Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat.The extending spectrum of NPC1-related human disorders: from Niemann-Pick C1 Disease to obesity.Recent neuroimaging, neurophysiological, and neuropathological advances for the understanding of NPC.Tolerance of chronic HDACi treatment for neurological, visceral and lung Niemann-Pick Type C disease in mice.Linear Cyclodextrin Polymer Prodrugs as Novel Therapeutics for Niemann-Pick Type C1 Disorder.
P2860
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P2860
Chronic administration of an HDAC inhibitor treats both neurological and systemic Niemann-Pick type C disease in a mouse model
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Chronic administration of an H ...... ype C disease in a mouse model
@ast
Chronic administration of an H ...... ype C disease in a mouse model
@en
Chronic administration of an H ...... ype C disease in a mouse model
@nl
type
label
Chronic administration of an H ...... ype C disease in a mouse model
@ast
Chronic administration of an H ...... ype C disease in a mouse model
@en
Chronic administration of an H ...... ype C disease in a mouse model
@nl
prefLabel
Chronic administration of an H ...... ype C disease in a mouse model
@ast
Chronic administration of an H ...... ype C disease in a mouse model
@en
Chronic administration of an H ...... ype C disease in a mouse model
@nl
P2093
P2860
P3181
P1476
Chronic administration of an H ...... ype C disease in a mouse model
@en
P2093
Kasturi Haldar
Md Suhail Alam
Michelle Getz
P2860
P304
P3181
P356
10.1126/SCITRANSLMED.AAD9407
P407
P577
2016-02-17T00:00:00Z