Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
about
Megakaryocyte biology and related disorders"UnPAKing" human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infectionThermal stability of the human immunodeficiency virus type 1 (HIV-1) receptors, CD4 and CXCR4, reconstituted in proteoliposomes.Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity.Novel compounds containing multiple guanide groups that bind the HIV coreceptor CXCR4.Attachment and fusion inhibitors potently prevent dendritic cell-driven HIV infectionSmall molecule inhibitors of CXCR4.HIV entry inhibitors and their potential in HIV therapyMethodology of pulsed photoacoustics and its application to probe photosystems and receptors.Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaquesEnfuvirtide: the first HIV fusion inhibitor.The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis.Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.Exploratory studies on development of the chemokine receptor CXCR4 antagonists toward downsizing.Chemokine receptors and other G protein-coupled receptors.Antibody epitopes on g protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers.A future perspective on the development of chemokine receptor CXCR4 antagonists.Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells.HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry.Determining human immunodeficiency virus coreceptor use in a clinical setting: degree of correlation between two phenotypic assays and a bioinformatic model.Mapping the ligand-binding site on a G protein-coupled receptor (GPCR) using genetically encoded photocrosslinkers.Prevention of murine experimental autoimmune encephalomyelitis by in vivo expression of a novel recombinant immunotoxin DT390-RANTES.Trofile HIV co-receptor usage assay.Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion.Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor.Update on the development of HIV entry inhibitors
P2860
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P2860
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
description
2004 nî lūn-bûn
@nan
2004 թուականին հրատարակուած գիտական յօդուած
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2004 թվականին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年学术文章
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2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
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2004年學術文章
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name
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@ast
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@en
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@nl
type
label
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@ast
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@en
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@nl
prefLabel
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@ast
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@en
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@nl
P356
P1476
Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs
@en
P2093
Christoph Seibert
P304
P356
10.2174/1381612043384312
P407
P577
2004-01-01T00:00:00Z