Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites
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Molecular Insight into Substrate Recognition and Catalysis of Baeyer–Villiger Monooxygenase MtmOIV, the Key Frame-Modifying Enzyme in the Biosynthesis of Anticancer Agent MithramycinA novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activityAn intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI)Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)ABC transporters in CSCs membranes as a novel target for treating tumor relapse.Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.Full-Length Enrich c-DNA Libraries-Clear Cell-Renal Cell CarcinomaDNA-binding small molecules as inhibitors of transcription factors.The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP.Quantitative determination of mithramycin in human plasma by a novel, sensitive ultra-HPLC-MS/MS method for clinical pharmacokinetic application.Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.Identification of inhibitors of ovarian cancer stem-like cells by high-throughput screening.Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' modeEPS8 inhibition increases cisplatin sensitivity in lung cancer cells.A cell-based high-throughput screen to identify synergistic TRAIL sensitizers.Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells.A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.XIAP-targeting drugs re-sensitize PIK3CA-mutated colorectal cancer cells for death receptor-induced apoptosis.Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dicationDimerization and DNA recognition rules of mithramycin and its analoguesThe role of TRAIL death receptors in the treatment of hematological malignancies.Hypoxia regulates TRAIL sensitivity of colorectal cancer cells through mitochondrial autophagy.TNF related apoptosis-inducing ligand and its receptors in ocular tumors.X-linked inhibitor of apoptosis protein - a critical death resistance regulator and therapeutic target for personalized cancer therapy.Sp1 and the 'hallmarks of cancer'.Induction of ER Stress-Mediated Apoptosis by α-Lipoic Acid in A549 Cell Lines.Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma.Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells.Regulation of RON tyrosine kinase-mediated invasion of breast cancer cells.The long noncoding RNA XIAP-AS1 promotes XIAP transcription by XIAP-AS1 interacting with Sp1 in gastric cancer cellsHeterotrimeric stimulatory GTP-binding proteins inhibit cisplatin-induced apoptosis by increasing X-linked inhibitor of apoptosis protein expression in cervical cancer cells.Wild-type PABPN1 is anti-apoptotic and reduces toxicity of the oculopharyngeal muscular dystrophy mutation.Mithramycin A Enhances Tumor Sensitivity to Mitotic Catastrophe Resulting From DNA Damage.Mithramycin A suppresses basal triple-negative breast cancer cell survival partially via down-regulating Krüppel-like factor 5 transcription by Sp1.
P2860
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P2860
Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites
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2006 nî lūn-bûn
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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
@zh-hant
2006年論文
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2006年論文
@zh-mo
2006年論文
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2006年论文
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name
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@ast
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@en
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@nl
type
label
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@ast
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@en
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@nl
prefLabel
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@ast
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@en
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@nl
P2093
P3181
P1476
Mithramycin A sensitizes cance ...... ene promoter through Sp1 sites
@en
P2093
Eun Mi Jung
Jong-Wook Park
Jung Tae Lee
Kyeong Sook Choi
Tae-Jin Lee
Taeg Kyu Kwon
P304
P3181
P356
10.1158/1535-7163.MCT-06-0426
P407
P577
2006-11-01T00:00:00Z