The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
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Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug SensitivityThe challenges of tumor genetic diversity.Bioinformatics and Drug Discovery."Big Data" for Breast Cancer: Where to look and what you will findIntersect-then-combine approach: improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers.AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer.The role of MDM2 and MDM4 in breast cancer development and prevention.ΔNp63α is a common inhibitory target in oncogenic PI3K/Ras/Her2-induced cell motility and tumor metastasis.The NF1 somatic mutational landscape in sporadic human cancers.The AURORA pilot study for molecular screening of patients with advanced breast cancer-a study of the breast international group'Big data' approaches for novel anti-cancer drug discovery.Genome-wide screen identifies a novel prognostic signature for breast cancer survival.Increased genomic burden of germline copy number variants is associated with early onset breast cancer: Australian breast cancer family registry.Clinical outcomes based on multigene profiling in metastatic breast cancer patientsIntegrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome.Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line."UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses.Role of steroid receptor and coregulator mutations in hormone-dependent cancers.The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives.The Mechanistic Role of the Calcium-Activated Chloride Channel ANO1 in Tumor Growth and Signaling.Marked for death: targeting epigenetic changes in cancer.A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer.Patient-derived xenograft (PDX) models in basic and translational breast cancer research.The Cellular Origin and Evolution of Breast Cancer.Sample preparation method considerations for integrated transcriptomic and proteomic analysis of tumors.Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor α in breast cancer cells.Characterization of potential driver mutations involved in human breast cancer by computational approaches.Mutational Signatures in Breast Cancer: The Problem at the DNA LevelThe Spectrum of Triple-Negative Breast Disease: High- and Low-Grade Lesions.Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families.Mutant p53 dictates the oncogenic activity of c-Abl in triple-negative breast cancers.Daurinol blocks breast and lung cancer metastasis and development by inhibition of focal adhesion kinase (FAK).Identification of a novel p53 target, COL17A1, that inhibits breast cancer cell migration and invasionThe BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.Signatures derived from increase in SHARPIN gene copy number are associated with poor prognosis in patients with breast cancer.Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer.Lunatic Fringe and p53 Cooperatively Suppress Mesenchymal Stem-Like Breast Cancer.HOXC8 regulates self-renewal, differentiation and transformation of breast cancer stem cells.Revisiting the impact of age and molecular subtype on overall survival after radiotherapy in breast cancer patients.
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P2860
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
description
2016 nî lūn-bûn
@nan
2016 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
The somatic mutation profiles ...... and transcriptomic landscapes
@ast
The somatic mutation profiles ...... and transcriptomic landscapes
@en
The somatic mutation profiles ...... and transcriptomic landscapes
@nl
type
label
The somatic mutation profiles ...... and transcriptomic landscapes
@ast
The somatic mutation profiles ...... and transcriptomic landscapes
@en
The somatic mutation profiles ...... and transcriptomic landscapes
@nl
prefLabel
The somatic mutation profiles ...... and transcriptomic landscapes
@ast
The somatic mutation profiles ...... and transcriptomic landscapes
@en
The somatic mutation profiles ...... and transcriptomic landscapes
@nl
P2093
P2860
P50
P3181
P356
P1476
The somatic mutation profiles ...... and transcriptomic landscapes
@en
P2093
Arnie Purushotham
Arusha Oloumi
Bernard Pereira
Dana W Y Tsui
David R Bentley
Elena Provenzano
Hans-Kristian Moen Vollan
Helen A Bardwell
Helen Northen
P2860
P2888
P3181
P356
10.1038/NCOMMS11479
P407
P50
P577
2016-05-10T00:00:00Z
P6179
1050455938