Mapping the transition state and pathway of protein folding by protein engineering
about
Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand bindingSpecific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis.The protein-folding problem: the native fold determines packing, but does packing determine the native fold?Many local motions cooperate to produce the adenylate kinase conformational transitionEvaluating beta-turn mimics as beta-sheet folding nucleatorsFrom snapshot to movie: phi analysis of protein folding transition states taken one step furtherProtein folding: then and nowCharacterization of protein-folding pathways by reduced-space modelingInsights into Coupled Folding and Binding Mechanisms from Kinetic StudiesTranslating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: cardiac metalloproteinase actions (CarMA) postulatesUnfolding simulations reveal the mechanism of extreme unfolding cooperativity in the kinetically stable alpha-lytic proteaseUsing flexible loop mimetics to extend -value analysis to secondary structure interactionsHow FMN binds to anabaena apoflavodoxin: a hydrophobic encounter at an open binding siteSolvation in protein folding analysis: Combination of theoretical and experimental approachesImplementation of a k/k0 Method to Identify Long-Range Structure in Transition States during Conformational Folding/Unfolding of ProteinsTheoretical and experimental demonstration of the importance of specific nonnative interactions in protein foldingA transient and low-populated protein-folding intermediate at atomic resolutionNonnative Interactions in the FF Domain Folding Pathway from an Atomic Resolution Structure of a Sparsely Populated Intermediate: An NMR Relaxation Dispersion StudyFunctional modulation of a protein folding landscape via side-chain distortionDirected evolution converts subtilisin E into a functional equivalent of thermitaseExtreme stabilization of a thermolysin-like protease by an engineered disulfide bondThe protein folding problemStructural determinants of the stability of thermolysin-like proteinasesOn the precision of experimentally determined protein folding rates and phi-valuesCooperative transition between open and closed conformations in potassium channelsAtomic-level characterization of the structural dynamics of proteinsDevelopment and Application of a High Throughput Protein Unfolding Kinetic AssayConstructing sequence-dependent protein models using coevolutionary information.Mapping the structure of amyloid nucleation precursors by protein engineering kinetic analysis.A residue in helical conformation in the native state adopts a β-strand conformation in the folding transition state despite its high and canonical Φ-value.Kinetic consequences of native state optimization of surface-exposed electrostatic interactions in the Fyn SH3 domain.Mutational investigation of protein folding transition states by Phi-value analysis and beyond: lessons from SH3 domain folding.The transition state for folding of an outer membrane protein.The osmolyte trimethylamine-N-oxide stabilizes the Fyn SH3 domain without altering the structure of its folding transition state.Sparsely populated folding intermediates of the Fyn SH3 domain: matching native-centric essential dynamics and experimentTransition states for protein folding have native topologies despite high structural variability.Formation of the folding nucleus of an SH3 domain investigated by loosely coupled molecular dynamics simulations.Calculation of mutational free energy changes in transition states for protein folding.Direct molecular dynamics observation of protein folding transition state ensembleMolecular dynamics simulations of protein folding from the transition state.
P2860
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P2860
Mapping the transition state and pathway of protein folding by protein engineering
description
1989 nî lūn-bûn
@nan
1989 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Mapping the transition state and pathway of protein folding by protein engineering
@ast
Mapping the transition state and pathway of protein folding by protein engineering
@en
Mapping the transition state and pathway of protein folding by protein engineering
@nl
type
label
Mapping the transition state and pathway of protein folding by protein engineering
@ast
Mapping the transition state and pathway of protein folding by protein engineering
@en
Mapping the transition state and pathway of protein folding by protein engineering
@nl
prefLabel
Mapping the transition state and pathway of protein folding by protein engineering
@ast
Mapping the transition state and pathway of protein folding by protein engineering
@en
Mapping the transition state and pathway of protein folding by protein engineering
@nl
P2093
P356
P1433
P1476
Mapping the transition state and pathway of protein folding by protein engineering
@en
P2093
A Matouschek
A R Fersht
J T Kellis
P2888
P356
10.1038/340122A0
P407
P577
1989-07-13T00:00:00Z
P5875
P6179
1010152468