Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase
about
Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria familiesTransition-state inhibitors of purine salvage and other prospective enzyme targets in malariaAnatomy of a proficient enzyme: The structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analogThe Leishmania donovani UMP Synthase Is Essential for Promastigote Viability and Has an Unusual Tetrameric Structure That Exhibits Substrate-controlled OligomerizationA bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Purification and characterization of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinaseBiochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosisProton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituentQM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysisPurine and pyrimidine pathways as targets in Plasmodium falciparum.Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State.Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans.Molecular, kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphoribosyltransferase.Inhibition of de novo pyrimidine synthesis in growing potato tubers leads to a compensatory stimulation of the pyrimidine salvage pathway and a subsequent increase in biosynthetic performance.Selective activities of STAMPs against Streptococcus mutans.orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphateorotidine 5'-monophosphate => uridine 5'-monophosphate + CO2
P2860
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P2860
Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase
description
1996 nî lūn-bûn
@nan
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@ast
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@en
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@nl
type
label
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@ast
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@en
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@nl
prefLabel
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@ast
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@en
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@nl
P2093
P2860
P356
P1476
Intrinsic activity and stabili ...... ine-5'-phosphate decarboxylase
@en
P2093
P2860
P304
P356
10.1074/JBC.271.18.10704
P407
P577
1996-05-03T00:00:00Z