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The bacterial ribosome as a target for antibiotics

The bacterial ribosome as a target for antibiotics

http://www.wikidata.org/entity/Q28279726

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The evolutionary rate of antibacterial drug targets Multidrug resistance in bacteria RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA A proteome-wide protein interaction map for Campylobacter jejuni Recent Advances in Developing Small Molecules Targeting Nucleic Acid tRNAs as antibiotic targets Structural basis for hygromycin B inhibition of protein biosynthesis Structure of the Thiostrepton Resistance Methyltransferase{middle dot}S-Adenosyl-L-methionine Complex and Its Interaction with Ribosomal RNA The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site Allosteric control of the ribosome by small-molecule antibiotics.A structural basis for streptomycin-induced misreading of the genetic code Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit 4′-O-substitutions determine selectivity of aminoglycoside antibiotics Targeting Antibiotic Resistance Impact of ribosomal modification on the binding of the antibiotic telithromycin using a combined grand canonical monte carlo/molecular dynamics simulation approach Computational Discovery of Putative Leads for Drug Repositioning through Drug-Target Interaction Prediction Trans-translation is essential in the human pathogen Legionella pneumophila Design of a bioactive small molecule that targets r(AUUCU) repeats in spinocerebellar ataxia 10 Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells Differential expression of ribosomal proteins in a human metastasis model identified by coupling 2-D liquid chromatography and mass spectrometry.Spirotetronate polyketides as leads in drug discovery.Effects of streptomycin resistance mutations on posttranslational modification of ribosomal protein S12.Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli Selection of small peptides, inhibitors of translation.1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams.Methods to enable the design of bioactive small molecules targeting RNA.Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin.Large facilities and the evolving ribosome, the cellular machine for genetic-code translation A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.Pterostilbene, a Methoxylated Resveratrol Derivative, Efficiently Eradicates Planktonic, Biofilm, and Intracellular MRSA by Topical Application.A novel Erm monomethyltransferase in antibiotic-resistant isolates of Mannheimia haemolytica and Pasteurella multocida.Defining the RNA internal loops preferred by benzimidazole derivatives via 2D combinatorial screening and computational analysis Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida New trends in aminoglycosides use.Antibiotic susceptibility profiles of Lactobacillus reuteri and Lactobacillus fermentum.

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P2860

The bacterial ribosome as a target for antibiotics

http://www.wikidata.org/entity/Q28279726

description

2005 nî lūn-bûn

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2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

The bacterial ribosome as a target for antibiotics

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The bacterial ribosome as a target for antibiotics

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The bacterial ribosome as a target for antibiotics

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The bacterial ribosome as a target for antibiotics

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The bacterial ribosome as a target for antibiotics

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prefLabel

The bacterial ribosome as a target for antibiotics

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The bacterial ribosome as a target for antibiotics

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The bacterial ribosome as a target for antibiotics

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Nature Reviews Microbiology

P1476

The bacterial ribosome as a target for antibiotics

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P2093

Jacob Poehlsgaard

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P2860

Ribosomal Crystallography: Initiation, Peptide Bond Formation, and Amino Acid Polymerization are Hampered by Antibiotics

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

The structural basis of ribosome activity in peptide bond synthesis

Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution

Structure of the 30S ribosomal subunit

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit

Crystal structure of the ribosome at 5.5 A resolution

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870-81

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scholarly article

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1129140

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10.1038/NRMICRO1265

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11

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3

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Stephen Douthwaite

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2005-11-01T00:00:00Z

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7506199

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